Original Articles

THE RISK OF SQUAMOUS CELL CARCINOMA ON HUMAN PAPILLOMAVIRUS TYPE-16 INFECTION IN BALI

I G. A. S. Mahendra-Dewi , I K. Suwiyoga

I G. A. S. Mahendra-Dewi
Anatomical Pathology Department, Faculty of Medicine Udayana University, Bali-Indonesia. Email: mahendra_dewi@yahoo.com

I K. Suwiyoga
Obstetric and Gynecologic Departments, Faculty of Medicine Udayana University, Bali-Indonesia
Online First: November 21, 2013 | Cite this Article
Mahendra-Dewi, I., Suwiyoga, I. 2013. THE RISK OF SQUAMOUS CELL CARCINOMA ON HUMAN PAPILLOMAVIRUS TYPE-16 INFECTION IN BALI. Indonesia Journal of Biomedical Science 7(1): 27-29.


The high risk of human papillomavirus (HPV) have already known widely and accepted as a 
causative agent for cervical cancer. Epidemiologically, predominant high-risk is HPV-16 and squamous cell
carcinomas (SCC) is the most common histological type. HPV genotype probably correlates to histologic
type. This study aims to determine how many fold is the risk of SCC on HPV-16 infection. This is a case
control with SCC HPV-16 positive as the cases and SCC HPV-16 negative as the controls. Tissues  diagnosed as SCC and non SCC was paraffin-embedded. SPF-10 and specific E7-primer types by LiPA were employed for genotyping of HPV-16. ï£ï€²ï€ was applied to analyze the correlation. A number of 65 SCC consisted of 33 cases and 32 controls were observed in this study. The risk of SCC on HPV-16 infection was 3.40-fold (95% CI = 1.44-8.03; p = 0.004) compare with HPV-16 negative. Controls in this study consist of 18 (27.69%) of HPV-18, 9 (13.85%) of HPV-52, and 5 (7.69%) of other HPV types. The mean-age of case group and control group infected by HPV were 52.28 ± 12.43 and 47.70 ± 8.02 year, respectively (p = 0.02). HPV-16 infection caused SCC is 3.5 more than other high risk group.
No Supplementary Material available for this article.
Article Views      : 17
PDF Downloads : 7