Original Articles

CTx serum level in mice post-ovariectomy after administration of sweet potato extract (Ipomoea batatas) is lower than without administration of sweet potato extract (Ipomoea batatas)

Tungka Melissa , I Ketut Suyasa, Anak Agung Wiradewi Lestari, Putu Astawa

Tungka Melissa
Department of Orthopaedic and Traumatology, Faculty of Medicine Udayana University/Sanglah Hospital, Bali, Indonesia. Email: melissapingkan@yahoo.com

I Ketut Suyasa
Department of Orthopaedic and Traumatology, Faculty of Medicine Udayana University/Sanglah Hospital, Bali, Indonesia

Anak Agung Wiradewi Lestari
Department of Orthopaedic and Traumatology, Faculty of Medicine Udayana University/Sanglah Hospital, Bali, Indonesia

Putu Astawa
Department of Orthopaedic and Traumatology, Faculty of Medicine Udayana University/Sanglah Hospital, Bali, Indonesia
Online First: June 13, 2018 | Cite this Article
Melissa, T., Suyasa, I., Lestari, A., Astawa, P. 2018. CTx serum level in mice post-ovariectomy after administration of sweet potato extract (Ipomoea batatas) is lower than without administration of sweet potato extract (Ipomoea batatas). Indonesia Journal of Biomedical Science 12(2). DOI:10.15562/ijbs.v12i2.161


Background: Osteoporosis is a systemic bone disease characterized by a decrease in bone mass. Postmenopausal osteoporosis is the most common osteoporosis. In postmenopausal osteoporosis, the increase in bone resorption is due to estrogen deficiency. Phytoestrogens are natural substances that can affect estrogenic activity. One of the plants that have phytoestrogens substances is sweet potato (Ipomoea batatas). Sweet potato (Ipomoea batatas) contains anthocyanin that acts as phytoestrogens agent to prevent osteoporosis in postmenopausal women. Aim: This study aimed to determine the effect of sweet potato extract administration toward CTx level. Methods: An experimental study of post-test control group design was done using 36 female Wistar mice. All mice underwent ovariectomy and were divided into two groups. The first group was given sweet potato extract 400 mg/day, while the second group did not receive any sweet potato extract. In the fourth week, the treatment effect was assessed by examining serum C terminal telopeptide (CTx) level that was taken from mice blood. Results: Statistical analysis found that the mean serum C terminal telopeptide (CTx) levels in mice receiving sweet potato extract were lower than those without the sweet potato extract. Independent t-test that was done on the sample found significant differences with p = 0.000 (p <0.05). Conclusion: Administration of sweet potato extract on post-ovariectomy mice resulted in a lower level of serum C terminal telopeptide (CTx) than those without sweet potato extract. 

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