Skip to main content Skip to main navigation menu Skip to site footer

The relationship between forced expiratory volume 1 (FEV 1) with 25(OH) vitamin D level and hs-CRP in COPD in H. Adam Malik General Hospital Medan

  • Katarina Julike ,
  • Amira Permatasari Tarigan ,
  • Ratna Akbari Ganie ,


Background: The number of people with COPD according to WHO was increasing to 400 million people by 2020 and half of these occur in Indonesia. The incidence of COPD in Indonesia ranks 5th highest in the world at 7.8 million. COPD was a non-communicable disease that is thought to be closely related to the increasing number of smokers, especially in young age groups. This study aims to determine between FEV1 with 25 (OH) vitamin D level and hs-CRP in COPD patients.

Methods: This study was a cross-sectional method conducted in H. Adam Malik General Hospital Medan, from January to June 2018 on 51 COPD patients who were treated at Pulmonology Outpatient Clinic. Spirometry examination, 25 (OH) levels of vitamin D, and hs-CRP was examined. Data were analyzed statistically using SPSS version 16 for windows.

Results: Total 51 patients who participated in the study were all male. Based on Pearson Correlation Test, FEV1 value of COPD patients did not show a significant correlation with levels of 25 (OH) vitamin D. While the Spearman Rank Correlation Test shown significant correlation with hs-CRP levels. Anova test results and Kruskal Wallis test on levels of 25 (OH) vitamin D, hs-CRP and Leukocyte counts shown no significant differences with GOLD criteria. Conclusion: The mean FEV1 value of COPD patients, 25 (OH) levels of vitamin D and the number of Leukocytes shown no significant statistical difference, whereas the higher the FEV1value, the lower the hs-CRP.



  1. Trihono. Riset Kesehatan Dasar (Riskesdas) 2013. Jakarta: Badan Penelitian dan Pengembangan Kementrian Kesehatan RI. 2013. (Indonesian)
  2. Ahmad A, Permatasari A. Karakteristik Penderita Penyakit Paru Obstruksi Kronik (PPOK) yang berobat jalan di RSUP.H. Adam Malik Medan pada 2015. Tesis penelitian. Repository USU. 2015. (Indonesian)
  3. Gultom YE. Perbandingan kadar CRP penderita PPOK stabil dengan eksaserbasi di RSUP H. Adam Malik Medan. Tesis. Repositori USU. 2014. (Indonesian)
  4. Torress JP, Cordoba-Lanus E, Lopez-Aguilar C, de Fuentes MM, de Gracini AM, Aguirre-Jaime A. C-reactive protein levels and clinical important predictive outcomes in stable COPD patients. Eur Respir J. 2006;27:902-7.
  5. Hurst JR, Donaldson GC, Perera WR, Wilkinson TM, Bilello JA, Hagan GW, et al. Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;174:867-74.
  6. Tsiligianni I., van der Molen. A systematic review of the role of vitamin insufficiencies and supplementation in COPD. Respiratory Research. 2010;11:171.
  7. Molen. A systematic review of the role of vitamin insufficiencies and supplementation in COPD. Respiratory Research. 2010;11:171.
  8. Herr et al. The role of vitamin D in pulmonary disease:
  9. COPD, asthma, infection, and cancer. Respiratory Research. 2011;12:31.
  10. Janssens W, Bouillon R, Claes B, Carremans C, Lehouck A, Buysschaert I, et al. Vitamin D Deficiency is Highly Prevalent in COPD and Correlates with Variants in the Vitamin D Binding Gene. Thorax 2010. 2010;65:215-220.
  11. [GOLD] Global Initiative FOR Chronic Obstructive Lung Disease. Pocket guide to COPD diagnosis, management, and prevention. GOLD, Medical Communication Resources, Inc. 2017.
  12. Perhimpunan Dokter Paru Indonesia. Penyakit paru obstruksi kronik, pedoman praktis diagnosis dan penatalaksanaan di Indonesia. Jakarta: Indah offisetgrafika. 2011:1-86. (Indonesian)
  13. Matherrs CD, Loncar D. Projection of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):2011-30.
  14. Ikawati Z. Farmakoterapi Penyakit Sistem Pernapasam. Pustaka Adipura, Yogyakarta. 2007. (Indonesian)
  15. Ohno Y, Koyama H, Nogami M, Takenaka D, Matsumoto S, Obara M et al. Dynamic oxygen-enhanced MRI versus quantitative CT: pulmonary functional loss assessment and clinical stage classification of smoking-related COPD. AJR. 2008;190:93-9.
  16. Nugraha I. Hubungan derajat berat merokok berdasarkan indeks Brinkman dengan derajat berat PPOK tahun 2010. Penelitian Akper Patria Husada Surakarta. Surakarta. 2010. (Indonesian)
  17. Bihar S. Korelasi derajat obstruksi dengan transport mukosiliar hidung penderita penyakit paru obstruktif kronik stabil di rumah Sakit Umum Pusat Haji Adam Malik Medan dan BP4 Medan tahun 2012. Tesis. Departemen Pulmonologi dan Ilmu Kedokteran Respirasi Fakultas Kedokteran Universitas Sumatera Utara. Medan.2012. (Indonesian)
  18. Lee JY, So TY, Thackray J. A review on vitamin D deficiency treatment in pediatric patients. J PediatrPharmacolTher. 2013;18:277-91.
  19. Pepys MB, Hirschfield GM. C-Reactive Protein: A Critical Update. The Journal of Clinical Investigation. 2003;111:1805-1811.
  20. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004;59(7):574-580.
  21. Menon B, Kaur C, Vardhan H, Gopi A, Dar MY. Evaluation of vitamin D, IL-6 and hs-CRP in different stages of COPD and their correlation with severity of disease and frequency of exacerbations. International Journal of Allergy Medications. 2016:2(2):1-4.
  22. Moberg M, Vestbo J, Martinez G, Lange P, Ringbeak T. Prognostic value c-reactive protein, leukocytes, and vitamin D in severe COPD. The Scientific World Journal. 2014;2014:1-8
  23. Alavi SA, Soati F, Forghanparast K. Hs-CRP in patients with acute exacerbation of COPD. Iran Red Crescent Medical Journal. 2011;13(10):713-718.

How to Cite

Julike, K., Tarigan, A. P., & Ganie, R. A. (2019). The relationship between forced expiratory volume 1 (FEV 1) with 25(OH) vitamin D level and hs-CRP in COPD in H. Adam Malik General Hospital Medan. Indonesia Journal of Biomedical Science, 13(1), 16–21.




Search Panel

Katarina Julike
Google Scholar
IJBS Journal

Amira Permatasari Tarigan
Google Scholar
IJBS Journal

Ratna Akbari Ganie
Google Scholar
IJBS Journal