Original Articles

Correlation of lactate levels with sequential organ failure assessment (SOFA) score in sepsis patients in H. Adam Malik Hospital Medan

Jemie Jemie , Ricke Loesnihari, Achsanuddin Hanafie

Jemie Jemie
Postgraduate Program in Clinical Pathology Specialization,Faculty of Medicine, University of Sumatera Utara. Email: lim_jemie@yahoo.co.id

Ricke Loesnihari
Department of Clinical Pathology,Faculty of Medicine,University of Sumatera Utara

Achsanuddin Hanafie
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Sumatera Utara
Online First: June 01, 2019 | Cite this Article
Jemie, J., Loesnihari, R., Hanafie, A. 2019. Correlation of lactate levels with sequential organ failure assessment (SOFA) score in sepsis patients in H. Adam Malik Hospital Medan. Indonesia Journal of Biomedical Science 13(1): 26-30. DOI:10.15562/ijbs.v13i1.174


Introduction: Lactate is an intermediate metabolic that is non-toxic and were produced by all cells. In sepsis patients, increased lactate occurs due to tissue hypoperfusion and represent a sign of tissue hypoxia. A clinical scoring system such as Sequential Organ Failure Assessment (SOFA), was commonly utilized to assess the severity of sepsis periodically based on several clinically significant organ dysfunction. The purpose of this study was to investigate the correlation of lactate levels with SOFA scores on sepsis patients treated in ICU.

Method: This is a prospective cohort study, involving 57 patients with sepsis who met the inclusion and exclusion criteria. The blood lactate levels were measured, and the SOFA scores were calculated, which then analyzed with Spearman correlation test.

Results: There was a weak but significant correlation between lactate levels and 24-hour SOFA Score (r = 0.303, p = 0.022). An intermediate correlation was obtained with 48 hours SOFA Score (r = 0.449, p = 0.000). Organ dysfunction that plays a significant role in increased lactate in this study were the central nervous system, respiratory system, liver, and kidneys.

Conclusion: There was an association between lactate levels and SOFA scores at 24th and 48th hour. SOFA Score can be considered as proper parameters to evaluate the deterioration of septic patients treated in the ICU.

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