Biological activity of Spondias pinnata: A review

Dewa Ayu Agus Sri Laksemi

Dewa Ayu Agus Sri Laksemi
Department of Parasitology, Medical Faculty, Universitas Udayana. Email:
Online First: December 30, 2019 | Cite this Article
Laksemi, D. 2019. Biological activity of Spondias pinnata: A review. Indonesia Journal of Biomedical Science 13(2). DOI:10.15562/ijbs.v13i2.218

Background: Herbal products are a promising alternative strategy to overcome infection in the era of antibiotic resistance that began to occur. Natural products from plants that are applied in medicine are increasingly and are often used because of the minimal side effects, less toxicity.

Review: Characteristics and plant content of the same species are different depend on ecology and geographic condition of land where the plant is cultivated. “Loloh†is a traditional drink from Bali, one of which is quite well known is loloh cemcem which is often found mainly in the tourist village of Penglipuran Bangli. “Loloh cemcem†is made from “cemcem†leaves or “kedondong†leaves originating from other languages Spondias pinnata. Plants of the genus Spondias, consisting of 18 species, have been used as a traditional medicine to treat various diseases. This plant is widely cultivated commercially in multiple countries to be marketed locally and internationally. The present review highlights the current advances of phytochemical screening, pharmacologic effect, the molecular mechanism of action of Spondias pinnata in health.


Jain P., Hossain K., Reza H. 2014. Antioxidant and Antibacterial Activities of Spondias pinnata Kurz Leaves. European Journal of Medicinal Plants, 4(2): 183–195.

Sujarwo W, and Saraswaty V. 2017. Ethnobotanical uses of “cemcem” ( Spondias pinnata (L. F.) Kurz ; Anacardiaceae) leaves in Bali (Indonesia) and its antioxidant activity. Pharmacology online; 1:113-123.

Mondal S, Dash GK, Chhetree R. 2010. Anthelmintic Activity of Spondias pinnata (Linn. F) Kurz. Research Journal Pharmacognosy and Phytochemistry 2010; 2(2): 103-108

Vijetha PK, Hedge K, Shabaraya AR. 2018. Pharmacological Review on Spondias pinnata: The Indian Hog Plum. Inter. J Pharm. Chem. Res; 4(2): 141-45

Sameh S, Alsayed E, Milad R, Singab A. 2018. Genus Spondias: A Phytochemical and Pharmacological Review Evidence-based Complementary and Alternative Medicine; 4: 1-13

Kamal S, Akhter R, Tithi NA, Wadud MA, Narjish SN, Shahriar M, Bhuiyan MA. 2015. Biological investigations of the leaf extract of Spondias pinnata. IJPSR, 6(8): 3351-3358

Panda BK, Patro VJ, Mishra US, Subratkar. 2014. Comparative Study of Anti-Pyretic Activity between Acetone and Ethanol Stem Bark Extracts of Spondias pinnata (Linn.F) Kurz. Journal of Pharmaceutical, Chemical and Biological Sciences. 1(1):26-32

Bolatito SO, Olugbenga1 O, Mobolaji1 O, Oluwalana SA, Adeniran S, Inyang A. 2014. Phytochemical and antimicrobial screening of Spondias mombin, Senna occidentalis and Musa sapientum against Vibrio cholerae O1. Int J Curr Microbiol App Sci, 3(5): 948-961

Kishore H, Kaur B, Kalsi V, Suttee A. 2016. Effect of Ethanolic Extract of Spondias pinnata on Ischemia-Reperfusion Injury and Ischemic Preconditioning of Heart. Inter J. Pharmacog Phyto Res, 8(5): 865-870

Rao VG, Nayak S, Shetty B. 2018. Evaluation of Modulatory Effect of Combination of Spondias pinnata and Whey Preparation on Intestinal Antioxidants and Inflammatory Markers in Etoposide Induced Rat Model for Mucositis. Pharmacogn J, 10(4): 640–644.

Satpathy G., Tyagi YK., Gupta RK. 2011. Preliminary evaluation of nutraceutical and therapeutic potential of raw Spondias pinnata K., an exotic fruit of India. Food Research International, 44(7): 2076-87

Khatoon S, Siddiqui HH, Hussain T. 2015. Botanical and phytochemical evaluation of fruits of Spondias pinnata. De Pharmacia Lettre, 7(5): 276–280.

Attanayake AP, Jayatilaka K, Pathirana C, Mudduwa L. 2015. Toxicological investigation of Spondias pinnata (Linn. F.) Kurz. (Family: Anacardiaceae) Bark extract in Wistar rats. Inter J Green Pharm, 9(1): 26-31

Rahman MA, and Hamidul ANM. 2011. Antibacterial and cytotoxic activities of Spondias pinnata (Linn. F.) Kurz fruit extract. Indian Journal of Natural Products, 2(2): 265–267.

Kumar P and Sastry VG. 2013. Toxicity studies of ethanolic extract of Spondias pinnata, Kurz in Experimental Animals. Int J Med Chem Anal, 1(1): 17-22

Das J, Mannan A, Rahman M, Dinar AM, Uddin ME, Khan IN, et al. 2011. Chloroform and Ethanol Extract of Spondias pinnata and its Different Pharmacological activity Like- Antioxidant, Cytotoxic, Antibacterial Potential and Phytochemical Screening through In-Vitro Method. IJRPBS, 2(4): 1804-12

Asnani. 2017. Komponen Fitokimia Daun Kedondong Hutan (Spondias pinnata (LF) Kurz) serta Mekanisme Antibakteri dan Aplikasinya pada Ikan. [Dissertasion]; IPB: pp 1-88 [In Indonesian]

Gupta VK, Roy A, Nigam VK, Mukherjee K. 2010. Antimicrobial activity of Spondias pinnata resin. J Med Plants Res, 4(16): 1656-1661

Bora NS, Kakoti B, Gogoi B, Goswami AK. 2014. Ethno-Medicinal Claims, Phytochemistry and Pharmacology of Spondias pinnata: A Review. IJPSR, 5(4): 1138-1145

Hazra B, Biswas S, Mandal N. 2008. Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complementary and Alternative Medicine, 8(63): 1-10

Ghate NB, Hazra B, Sarkar R, Mandal N. 2014. In vitro anticancer activity of Spondias pinnata bark on human lung and breast carcinoma. Cytotechnology, 66: 209–218

No Supplementary Material available for this article.
Article Views      : 0
PDF Downloads : 0