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The effects of inflammatory factors on the formation of retinopathy of prematurity

  • I Wayan Eka Sutyawan ,
  • Ni Made Ayu Surasmiati ,
  • Ariesanti Tri Handayani ,
  • Ari Andayani ,
  • Ni Made Ari Suryathi ,
  • Johanes Ari Setiawan ,


Background: Retinopathy of prematurity (ROP) is the major cause of blindness in neonates worldwide. The incidence of preterm birth in live-born infants in Cipto Mangunkusumo Hospital in 2007 was 20.22%, and 71% of preterm babies have repaired retinopathy of prematurity.

Aim: This literature review aims to determine the effects of inflammatory factors on the formation of retinopathy of prematurity, such as interleukin-6, interleukin-1, COX-2 and Tumor Necrosis Factor-Alpha (TNF-α).

Conclusion: Hopefully, the information would help construct a more comprehensive approach toward patients with ROP.




  1. Palmer EA, Flynn JT, Hardy RJ, et al. Incident and early course of retinopathy of prematurity. Ophthalmology. 1991;98:1628-40
  2. Wheatley CM, et al. Retinopathy of prematurity: recent advances in our understanding. Br J Ophthalmol. 2002;86(6):696–700.
  3. McColm JR, Fleck BW. Retinopathy of prematurity: causation. Semin Neonatol. 2001;6(6):453–60.
  4. Csak K, Szabo V, Szabo A. Pathogenesis and genetic basis for retinopathy of prematurity. Front Biosci. 2006;11:908-20.
  5. Eva PR, Whitcher JP. Vaughan & Asbury’s General Ophthalmology 17th Ed. USA: The McGraw-Hill Company; 2007.
  6. Bashour M. Retinopathy of Prematurity. Emedicine; 2008.
  7. Renu AK, Oedenbach S. Role of Interleukin-1 in the Development of
  8. Retinopathy in Rats: Effect of Antioxidants. Invest Ophthalmol Vis Sci. 2004;45:4161–4166.
  9. Rivera JC, Holm M, Austeng D, Morken TS, Zhou T, Richard AB. Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies. J Neuroinflammation. 2017;14:1-14.
  10. Arti L. Retinopathy in prematurity. JKS. 2012;2:118 – 121.
  11. Kumar VA. Pathogenesis and Management of Retinopathy of Prematurity in Premature Infants. Pediatr Neonatal Nurs Open J. 2015;2(2):62-69.
  12. Rivera C, Saphiea P, Joyal J, Duhamel F, Shao Z, Sitaras N, Zhou E, Piccard, Lachapelle P, Chemtob S. Understanding Retinopathy of Prematurity: Update and Pathogenesis. Neonatology. 2011;100:343 – 353.
  13. Drumond HC, Volpe CMO, Agostini RM, Nogueira-Machado JA. Increased of Serum IL-1β and MDA in Diabetic and Hypertensive Retinopathies. Endocrinol Metab Int J. 2017;5(6): 00143.
  14. Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, et al. Ischemic neurons prevent vascular regeneration of neural tissue by secreting Semaphorin 3A. Blood. 2011;117:6024–6035.
  15. Stahl A, et al. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009;12(3):297–301.
  16. Sapieha P, Lachapelle P, Chemtob S. Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme
  17. of life. J Clin Invest. 2010;120(9):3022-3032.
  18. Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D. The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid. J Physiol Pharmacol. 2013;64(4):409–421.
  19. Hardy P, Dumont I, Bhattacharya M. Oxidants, nitric oxide and prostanoids in the developing ocular vasculature: a basis for ischemic retinopathy. Cardiovasc Res. 2010;47(3):489–509.
  20. Giannantonio C, Purcaro V, Cota F. Effectiveness of ketorolac tromethamine in prevention of severe retinopathy of prematurity. J Pediatr Ophthalmol Strabismus. 2011;48(4):247–251.
  21. Sobolewski C, Cerella C, Dicato M, Ghibelli L, Marc Diederich. The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies. International Journal of Cell Biology. 2010;2:1-2.
  22. Sennlaub F, Valamanesh FA. Vazquez AM, El-Asrar, Checchin D, Brault S, Gobeil F, et al. Cyclooxygenase-2 in Human and Experimental Ischemic Proliferative Retinopathy. Circulation. 2010;108:198-204.
  23. Friddle K. Pathogenesis of Retinopathy of Prematurity [Internet]. 2013 [cited 2019 Apr 7]. Available from:
  24. Nasution A. Risko factor for development of retinopaty prematurity. Sari Pediatri. 2001;3(3):152-56.
  25. Dammann O. Inflammation and Retinopathy of Prematurity. Acta Paediatr. 2004;99(7):975-77.
  26. Erlanggawati T, Prasetyo AA, Dewi PK. Description of Post High Concentration Oxygenation to Retina Vascularization (Experimental Study Retinopathy Of Prematurity In Wistar Rats. Diponegoro Medical Journal. 2018;7(4):1707-1719.
  27. Rojas M, Zhang W, Lee DL, Romero MJ, Nguyen DT, Shabrawey MA. Role of IL-6 in Angiotensin II-Induced Retinal Vascular Inflamation. Invest Ophthalmol Vis Sci. 2010;51(3):1709-18
  28. Hellstrom AC, Perruzzi M, Ju E, Engstrom AL, Hard JL, Liu K. Albertsson-Wikland B. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci. 2001;98:5804–5808.
  29. Smith LEH. Pathogenesis of Retinopathy of Prematurity. Growth Hormone & IGF Research. 2004;14:140-44.
  30. Sood BG, Madan A, Saha S, Schendel D, Thorsen P, Skogstrand K, Hougaard D, Shankaran S, Carlo W. Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. Pediatric Research. 2010;67(4):394-406.
  31. Ghasemi H. Roles of IL-6 in ocular inflammation: a review. Ocular immunology and inflammation. 2018;26(1):37-50.
  32. Sato T, Kusaka S, Shimojo H, Fujikado T. Simultaneous analyses of vitreous levels of 27 cytokines in eyes with retinopathy of prematurity. Ophthalmology. 2009;116(11):2165-2169.

How to Cite

Sutyawan, I. W. E., Surasmiati, N. M. A., Handayani, A. T., Andayani, A., Suryathi, N. M. A., & Setiawan, J. A. (2020). The effects of inflammatory factors on the formation of retinopathy of prematurity. Indonesia Journal of Biomedical Science, 14(1), 21–25.




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I Wayan Eka Sutyawan
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Ni Made Ayu Surasmiati
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Ariesanti Tri Handayani
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Ari Andayani
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Ni Made Ari Suryathi
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Johanes Ari Setiawan
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