Original Articles

The effects of inflammatory factors on the formation of retinopathy of prematurity

I Wayan Eka Sutyawan , Ni Made Ayu Surasmiati, Ariesanti Tri Handayani, Ari Andayani, Ni Made Ari Suryathi, Johanes Ari Setiawan

I Wayan Eka Sutyawan
Department of Ophthalmology, Faculty of Medicine, Universitas Udayana, Sanglah Hospital Denpasar, Bali, Indonesia Biomedical Doctoral Program, Universitas Udayana. Email: ekasutyawan@gmail.com

Ni Made Ayu Surasmiati
Department of Ophthalmology, Faculty of Medicine, Universitas Udayana, Sanglah Hospital Denpasar, Bali, Indonesia

Ariesanti Tri Handayani
Department of Ophthalmology, Faculty of Medicine, Universitas Udayana, Sanglah Hospital Denpasar, Bali, Indonesia

Ari Andayani
Department of Ophthalmology, Faculty of Medicine, Universitas Udayana, Sanglah Hospital Denpasar, Bali, Indonesia

Ni Made Ari Suryathi
Department of Ophthalmology, Faculty of Medicine, Universitas Udayana, Sanglah Hospital Denpasar, Bali, Indonesia

Johanes Ari Setiawan
Department of Ophthalmology, Faculty of Medicine, Universitas Udayana, Sanglah Hospital Denpasar, Bali, Indonesia
Online First: April 07, 2020 | Cite this Article
Sutyawan, I., Surasmiati, N., Handayani, A., Andayani, A., Suryathi, N., Setiawan, J. 2020. The effects of inflammatory factors on the formation of retinopathy of prematurity. Indonesia Journal of Biomedical Science 14(1): 21-25. DOI:10.15562/ijbs.v14i1.228


Background: Retinopathy of prematurity (ROP) is the major cause of blindness in neonates worldwide. The incidence of preterm birth in live-born infants in Cipto Mangunkusumo Hospital in 2007 was 20.22%, and 71% of preterm babies have repaired retinopathy of prematurity.

Aim: This literature review aims to determine the effects of inflammatory factors on the formation of retinopathy of prematurity, such as interleukin-6, interleukin-1, COX-2 and Tumor Necrosis Factor-Alpha (TNF-α).

Conclusion: Hopefully, the information would help construct a more comprehensive approach toward patients with ROP.

 

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