Case Reports

The Intracytoplasmic Sperm Injection (ICSI) technique in an infertile man with Hepatitis-B Virus (HBV) infection: a case report

I Gusti Ngurah Pramesemara , Zakiyatul Faizah, Ninik Darsini

I Gusti Ngurah Pramesemara
Andrology Specialist-1 Program, Medical Faculty of Universitas Airlangga, Dokter Soetomo General Hospital, Surabaya, Indonesia Andrology and Sexology Department, Medical Faculty of Universitas Udayana, Surabaya, Indonesia. Email: pramesemara@unud.ac.id

Zakiyatul Faizah
Medical Biology Department, Medical Faculty of Universitas Airlangga, Surabaya, Indonesia

Ninik Darsini
Medical Biology Department, Medical Faculty of Universitas Airlangga, Surabaya, Indonesia
Online First: October 14, 2020 | Cite this Article
Pramesemara, I., Faizah, Z., Darsini, N. 2020. The Intracytoplasmic Sperm Injection (ICSI) technique in an infertile man with Hepatitis-B Virus (HBV) infection: a case report. Indonesia Journal of Biomedical Science 14(2): 82-85. DOI:10.15562/ijbs.v14i2.231


Background: Several studies have suggested a relationship between chronic infection of the Human Hepatitis-B Virus (HBV) and infertility in men. HBV infection causes instability of spermatozoa chromosomes, interferes the parameters of semen analysis, and have risks to infecting fetus or embryo. In order to prevent the HBV infection, the Intracytoplasmic Sperm Injection (ICSI) procedure has been established. This case study aims to evaluate the ICSI technique conducted to an infertile man with HBV infection.

Case Description: We reported a case of a 42-year-old infertile male who had primary infertility for 11 years with positive HBsAg. Patients were given Tribulus terrestris and an antioxidant also referred to an internist colleague for the definitive treatment of Hepatitis-B. Then the patient and his wife were prepared to undergo an In-Vitro Fertilization (IVF) procedure by washing spermatozoa and ICSI. Routine evaluation for 15 days post-ICSI for the first time did not show biochemical signs of pregnancy in wives with negative β-hCG. 

Conclusion: It was concluded that the ICSI procedure could be considered in the action of IVF in infertile man with HBV due to no adverse effect recorded.

References

Liang TJ. Hepatitis B: the virus and disease. Hepatology. 2009;49(5 Suppl):S13‐S21.

Oger P, Yazbeck C, Gervais A, Dorphin B, Gout C, Jacquesson L, et al. Adverse effects of hepatitis B virus on sperm motility and fertilization ability during IVF. Reprod Biomed Online. 2011;23(2):207‐212.

Yano Y, Utsumi T, Lusida MI, Hayashi Y. Hepatitis B virus infection in Indonesia. World J Gastroenterol. 2015;21(38):10714‐10720.

Lee VC, Ng EH, Yeung WS, Ho PC. Impact of positive hepatitis B surface antigen on the outcome of IVF treatment. Reprod Biomed Online. 2010;21(5):712‐717.

Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Liu HX, et al. Effects of hepatitis B virus infection on human sperm chromosomes. World J Gastroenterol. 2003;9(4):736‐740.

Zheng Z, Zhao X, Hong Y, Xu B, Tong J, Xia L. The safety of intracytoplasmic sperm injection in men with hepatitis B. Arch Med Sci. 2016;12(3):587‐591.

Lao TT, Mak JSM, Li TC. Hepatitis B virus infection status and infertility causes in couples seeking fertility treatment-Indicator of impaired immune response?. Am J Reprod Immunol. 2017;77(4):10.1111/aji.12636.

Bu Z, Kong H, Li J, Wang F, Guo Y, Su Y, et al. Effect of male hepatitis B virus infection on outcomes of in vitro fertilization and embryo transfer treatment: insights from couples undergoing oocyte donation. Int J Clin Exp Med. 2014;7(7):1860‐1866.

Lam PM, Suen SH, Lao TT, Cheung LP, Leung TY, Haines C. Hepatitis B infection and outcomes of in vitro fertilization and embryo transfer treatment. Fertil Steril. 2010;93(2):480‐485.

Nie R, Jin L, Zhang H, Xu B, Chen W, Zhu G. Presence of hepatitis B virus in oocytes and embryos: a risk of hepatitis B virus transmission during in vitro fertilization. Fertil Steril. 2011;95(5):1667‐1671.

Atis G, Memis OF, Güngör HS, Arikan O, Saglican Y, Caskurlu T. Testicular polyarteritis nodosa mimicking testicular neoplasm. ScientificWorldJournal. 2010;10:1915‐1918.

Chen H, Ge HS, Lv JQ, Wu XM, Xi HT, Huang JY, Zhu CF, et al. Chronic hepatitis B virus infection in women is not associated with IVF/ICSI outcomes. Arch Gynecol Obstet. 2014;289(1):213‐217.

Steyaert SR, Leroux-Roels GG, Dhont M. Infections in IVF: review and guidelines. Hum Reprod Update. 2000;6(5):432‐441.

Pirwany IR, Phillips S, Kelly S, Buckett W, Tan SL. Reproductive performance of couples discordant for hepatitis B and C following IVF treatment. J Assist Reprod Genet. 2004;21(5):157‐161.

Elder K, Baker D, Ribes J. Infections, Infertility and Assisted Reproduction. Can Vet J. 2006;47(9):908

Hu XL, You JL, Pan HH, Li M, Zhu YM. The Presence of Hepatitis B and C Virus in Human Gametes and Embryos. In Borini A and Savasi V: Assisted Reproductive Technoloies and Infectious Diseases- A Guide to Management. Springer International Publishing. 2016: p.119-27.


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