Case Reports

The Intracytoplasmic Sperm Injection (ICSI) technique in an infertile man with Hepatitis-B Virus (HBV) infection: a case report

I Gusti Ngurah Pramesemara , Zakiyatul Faizah, Ninik Darsini

I Gusti Ngurah Pramesemara
Andrology Specialist-1 Program, Medical Faculty of Universitas Airlangga, Dokter Soetomo General Hospital, Surabaya, Indonesia Andrology and Sexology Department, Medical Faculty of Universitas Udayana, Surabaya, Indonesia. Email:

Zakiyatul Faizah
Medical Biology Department, Medical Faculty of Universitas Airlangga, Surabaya, Indonesia

Ninik Darsini
Medical Biology Department, Medical Faculty of Universitas Airlangga, Surabaya, Indonesia
Online First: October 14, 2020 | Cite this Article
Pramesemara, I., Faizah, Z., Darsini, N. 2020. The Intracytoplasmic Sperm Injection (ICSI) technique in an infertile man with Hepatitis-B Virus (HBV) infection: a case report. Indonesia Journal of Biomedical Science 14(2): 82-85. DOI:10.15562/ijbs.v14i2.231

Background: Several studies have suggested a relationship between chronic infection of the Human Hepatitis-B Virus (HBV) and infertility in men. HBV infection causes instability of spermatozoa chromosomes, interferes the parameters of semen analysis, and have risks to infecting fetus or embryo. In order to prevent the HBV infection, the Intracytoplasmic Sperm Injection (ICSI) procedure has been established. This case study aims to evaluate the ICSI technique conducted to an infertile man with HBV infection.

Case Description: We reported a case of a 42-year-old infertile male who had primary infertility for 11 years with positive HBsAg. Patients were given Tribulus terrestris and an antioxidant also referred to an internist colleague for the definitive treatment of Hepatitis-B. Then the patient and his wife were prepared to undergo an In-Vitro Fertilization (IVF) procedure by washing spermatozoa and ICSI. Routine evaluation for 15 days post-ICSI for the first time did not show biochemical signs of pregnancy in wives with negative β-hCG. 

Conclusion: It was concluded that the ICSI procedure could be considered in the action of IVF in infertile man with HBV due to no adverse effect recorded.


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