The association of prostatic inflammation grade with prostate volume and Prostate-Specific Antigen (PSA) value in Benign Prostate Hyperplasia (BPH) patients at Wahidin Sudirohusodo Hospital, Makassar
Adriandy Saleh
Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia. Email: dr.adriandysaleh@gmail.com
Syakri Sahrir
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
Muhammad Asykar Ansharullah Palinrungi
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
Khoirul Kholis
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
Syarif Bakri
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
Upik Anderiani Miskad
Anatomy Pathology Division, Anatomy Pathology Department, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
Arifin Seweng
Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia
- View PDF  | PDF | Print Article | Export Citation
Background: Prostate inflammation is commonly found in patients with benign prostate hyperplasia. On the histopathological examination, infiltration of the prostate gland's inflammatory cells was visible in chronic inflammation of the prostate. This study aims to determine prostate inflammation's association based on the histological examination with prostate volume and prostate-specific antigen (PSA) levels in benign prostate hyperplasia (BPH) patients.
Methods: A cross-sectional study was enrolled among 50 subjects with benign prostate enlargement observed at Wahidin Sudirohusodo hospital and its affiliate Hospitals in Indonesia from April to September 2018. The patients' data, including age, prostate volume, PSA level, and histopathology, were collected. Statistical tests using Chi-square were performed (considered significant if P <0.05). Data were analyzed using SPSS version 17 for Windows.
Results: Among 50 subjects, the age ranged from 51 to 85 years, with an average of 68.2 ± 8.9 years, while the prostate volume average remained at 64.2 ± 31.4 mm3. The average of the prostate-specific antigen (PSA) grade was 21.0 ± 30.2 ng/ml. The statistical analysis showed the association of age with the degree of inflammation (P = 0.25), the relationship of the prostate volume of the degree of inflammation (P = 0.46) and the value of PSA (P = 0.74). Among the 50 subjects examined, 100% were inflamed. The highest grade of inflammation was a moderate degree by 19 cases (38%). There is no significant relationship between the degree of inflammation with prostate volume and PSA's value (p>0.05). Besides, there is no significant association between the degree of prostate inflammation with prostate volume and the value PSA levels (p>0.05).
Conclusion: On the histopathological examination, inflammation was found in all research subjects with BPH, in which the highest degree of inflammation was at a moderate level.