Original Articles

The association of prostatic inflammation grade with prostate volume and Prostate-Specific Antigen (PSA) value in Benign Prostate Hyperplasia (BPH) patients at Wahidin Sudirohusodo Hospital, Makassar

Adriandy Saleh , Syakri Sahrir, Muhammad Asykar Ansharullah Palinrungi, Khoirul Kholis, Syarif Bakri, Upik Anderiani Miskad, Arifin Seweng

Adriandy Saleh
Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia. Email: dr.adriandysaleh@gmail.com

Syakri Sahrir
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

Muhammad Asykar Ansharullah Palinrungi
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

Khoirul Kholis
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

Syarif Bakri
Urology Division, Department of Surgery, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

Upik Anderiani Miskad
Anatomy Pathology Division, Anatomy Pathology Department, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

Arifin Seweng
Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia
Online First: December 10, 2020 | Cite this Article
Saleh, A., Sahrir, S., Palinrungi, M., Kholis, K., Bakri, S., Miskad, U., Seweng, A. 2020. The association of prostatic inflammation grade with prostate volume and Prostate-Specific Antigen (PSA) value in Benign Prostate Hyperplasia (BPH) patients at Wahidin Sudirohusodo Hospital, Makassar. Indonesia Journal of Biomedical Science 15(1): 5-7. DOI:10.15562/ijbs.v15i1.246


Background: Prostate inflammation is commonly found in patients with benign prostate hyperplasia. On the histopathological examination, infiltration of the prostate gland's inflammatory cells was visible in chronic inflammation of the prostate. This study aims to determine prostate inflammation's association based on the histological examination with prostate volume and prostate-specific antigen (PSA) levels in benign prostate hyperplasia (BPH) patients.

Methods: A cross-sectional study was enrolled among 50 subjects with benign prostate enlargement observed at Wahidin Sudirohusodo hospital and its affiliate Hospitals in Indonesia from April to September 2018. The patients' data, including age, prostate volume, PSA level, and histopathology, were collected. Statistical tests using Chi-square were performed (considered significant if P <0.05). Data were analyzed using SPSS version 17 for Windows.

Results: Among 50 subjects, the age ranged from 51 to 85 years, with an average of 68.2 ± 8.9 years, while the prostate volume average remained at 64.2 ± 31.4 mm3.  The average of the prostate-specific antigen (PSA) grade was 21.0 ± 30.2 ng/ml. The statistical analysis showed the association of age with the degree of inflammation (P = 0.25), the relationship of the prostate volume of the degree of inflammation (P = 0.46) and the value of PSA (P = 0.74). Among the 50 subjects examined, 100% were inflamed. The highest grade of inflammation was a moderate degree by 19 cases (38%). There is no significant relationship between the degree of inflammation with prostate volume and PSA's value (p>0.05). Besides, there is no significant association between the degree of prostate inflammation with prostate volume and the value PSA levels (p>0.05).

Conclusion: On the histopathological examination, inflammation was found in all research subjects with BPH, in which the highest degree of inflammation was at a moderate level.

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