Skip to main content Skip to main navigation menu Skip to site footer

Conjunctival Kaposi’s sarcoma in Acquired Immunodeficiency Syndrome (AIDS) patient: a case report

Abstract

Background: Kaposi’s sarcoma (KS) is malignant neoplasm of the vascular endothelium, caused by Human Herpes Virus 8 (HHV 8). Clinical variants consist of classic KS, iatrogenic KS, and AIDS KS. The manifestation of KS in the eye may occur in the eyelids, the lacrimal sac or gland, the orbit and bulbar or palpebral conjunctiva. This case study aims to demonstrate the incidental finding of conjunctival Kaposi sarcoma (KS) leading to acquired immunodeficiency syndrome (AIDS) diagnosis.

Case Presentation: A 34-years old male patient presented with a three-month history of progressively growing reddish mass in bulbar conjunctiva of the left eye. A mass with notable aggressive tumor characteristics heightened the suspicion for KS and comprehensive assessments were done accordingly. The patient was found to suffer from human immunodeficiency virus (HIV)/AIDS. Multistep approach treatment was commenced to treat AIDS-related KS and prevent recurrence in this case.

Conclusion: Patients with undiagnosed HIV infection would benefit from early diagnosis initiated by AIDS-defining illnesses such as KS. Given early identification and comprehensive management, KS abridged the time to diagnosis of HIV infection.

Section

References

  1. Antman K, Chang Y. Medical Progress: Kaposi Sarcoma. New England Journal of Medicine. 2000;342(14):1027-1038.
  2. Solivetti FM, Elia F, Latini A, Cota C, Cordiali-Fei P, Di Carlo A. AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?. J Exp Clin Cancer Res. 2011;30(1):40.
  3. Mikropoulos D, Mavrikakis I, Ziakas NG, Konstas AG, Boboridis KG. Kaposi's Sarcoma of the Bulbar Conjunctiva in an Immunocompetent Patient. Case Rep Ophthalmol. 2011;2(2):193-197.
  4. American Academy of Ophthalmology Staff. Ophthalmic Pathology and Intraocular Tumors. Basic and Clinical Science Course. Section 4. San Francisco: American Academy of Ophthalmology. 2016. p.82-103.
  5. Donovan C, Patel H, Shetty S, Bierman L, Lustbader JM, Oboh-Weilke AM. Aggressive conjunctival Kaposi sarcoma as the initial manifestation of acquired immunodeficiency syndrome. Am J Ophthalmol Case Rep. 2020;19:100832.
  6. Mika K, Pogrzebielski A, Dyduch G. Kaposi Sarcoma of the conjunctiva as the first manifestation of HIV infection. The American Journal of Case Reports. 2011;11:64-66.
  7. Maia S, Gomes M, Oliveira L, Torres P. Isolated Bulbar Conjunctival Kaposi's Sarcoma as a Primary Presentation of AIDS: A Case Report. Case Rep Ophthalmol Med. 2013;2013:469195.
  8. Kim YS, Sun HJ, Kim TH, Kang KD, Lee SJ. Ocular Manifestations of Acquired Immunodeficiency Syndrome. Korean J Ophthalmol. 2015;29(4):241-248.
  9. Kohanim S, Daniels AB, Huynh N, Chodosh J. Local treatment of Kaposi sarcoma of the conjunctiva. Int Ophthalmol Clin. 2011;51(4):183-192.
  10. Etemad SA, Dewan AK. Kaposi Sarcoma Updates. Dermatol Clin. 2019;37(4):505-517.
  11. Leder HA, Galor A, Peters GB, Kedhar SR, Dunn JP, Thorne JE. Resolution of conjunctival Kaposi sarcoma after institution of highly active antiretroviral therapy alone. Br J Ophthalmol. 2008;92(1):151.
  12. Qureshi YA, Karp CL, Dubovy SR. Intralesional interferon alpha-2b therapy for adnexal Kaposi sarcoma. Cornea. 2009;28(8):941-943.
  13. Jakob L, Metzler G, Chen KM, Garbe C. Non-AIDS associated Kaposi's sarcoma: clinical features and treatment outcome. PLoS One. 2011;6(4):e18397.
  14. Grimwade K, Swingler, G. Cotrimoxazole prophylaxis for opportunistic infections in adults with HIV. Cochrane Database Syst Rev. 2003;2003(3):CD003108.
  15. Günthard HF, Saag MS, Benson CA, del Rio C, Eron JJ, Gallant JE. et al. Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel. JAMA. 2016;316(2):191-210.

How to Cite

Utari, N. M. L., Simanjutak, E., Yuliawati, P., Djelantik, A. A. A. S., Kusumadjaja, I. M. A., & Utama, I. M. S. (2020). Conjunctival Kaposi’s sarcoma in Acquired Immunodeficiency Syndrome (AIDS) patient: a case report. Indonesia Journal of Biomedical Science, 14(2), 128–130. https://doi.org/10.15562/ijbs.v14i2.277

HTML
37

Total
0

Share

Search Panel

Ni Made Laksmi Utari
Google Scholar
Pubmed
IJBS Journal


Elbetty Simanjutak
Google Scholar
Pubmed
IJBS Journal


Putu Yuliawati
Google Scholar
Pubmed
IJBS Journal


Anak Agung Ayu Sukartini Djelantik
Google Scholar
Pubmed
IJBS Journal


I Made Agus Kusumadjaja
Google Scholar
Pubmed
IJBS Journal


I Made Susila Utama
Google Scholar
Pubmed
IJBS Journal