Case Reports

Pure prostatic ductal adenocarcinoma with elevated prostate-specific antigen level: a rare case report and literature review

Agus Rizal , Chaidir Arif Mochtar, Rainy Umbas, Stevano Lucianto, Meilania Saraswati, Sahat Matondang

Agus Rizal
Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Email: agusrizauro@gmail.com

Chaidir Arif Mochtar
Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Rainy Umbas
Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Stevano Lucianto
Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Meilania Saraswati
Department of Anatomical Pathology, Cipto Mangunkusumo, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Sahat Matondang
Department of Radiology, Cipto Mangunkusumo, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Online First: May 15, 2021 | Cite this Article
Rizal, A., Mochtar, C., Umbas, R., Lucianto, S., Saraswati, M., Matondang, S. 2021. Pure prostatic ductal adenocarcinoma with elevated prostate-specific antigen level: a rare case report and literature review. Indonesia Journal of Biomedical Science 15(1): 60-62. DOI:10.15562/ijbs.v15i1.293


Introduction: Prostatic ductal adenocarcinoma (PDA) is rare, representing approximately 0.4 to 0.8% of all prostate malignancies. It usually occurs in the prostatic urethra around verumontanum, its prognosis is generally considered to be worse compared to acinar adenocarcinoma.

Case description: We present a 75-year-old male with PDA with an elevated PSA level. PDA histologically characterized by pseudostratified columnar cells. It is associated with aggressive behavior with an overall poor prognosis. Although normal PSA is a common finding in those with PDA, the presence of elevated PSA levels should not be used to exclude the possibility of PDA.

Conclusion: PDA is a rare variant of prostate cancer which is histologically characterized by pseudostratified columnar cells. Although normal PSA is a frequent finding in those with PDA, the presence of elevated PSA should not be used to exclude the possibility of PDA.

References

Mazzucchelli R, Lopez-Beltran A, Cheng L, Scarpelli M, Kirkali Z, Montironi R. Rare and unusual histological variants of prostatic carcinoma: Clinical significance. BJU Int. 2008;102(10):1369-1374. doi:10.1111/j.1464-410X.2008.08074.x.

Samaratunga H, Delahunt B. Ductal adenocarcinoma of the prostate: current opinion and controversies. Anal Quant Cytol Histol. 2008;30(4):237-246.

Kim A, Kwon T, You D, et al. Clinicopathological features of prostate ductal carcinoma: Matching analysis and comparison with prostate acinar carcinoma. J Korean Med Sci. 2015;30(4):385-389. doi:10.3346/jkms.2015.30.4.385.

Eade TN, Al-Saleem T, Horwitz EM, Buyyounouski MK, Chen DYT, Pollack A. Role of radiotherapy in ductal (endometrioid) carcinoma of the prostate. Cancer. 2007;109(10):2011-2015. doi:10.1002/cncr.22644.

Tavora F, Epstein JI. High-grade prostatic intraepithelial neoplasialike ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases. Am J Surg Pathol. 2008;32(7):1060-1067. doi:10.1097/PAS.0b013e318160edaf.


No Supplementary Material available for this article.
Article Views      : 0
PDF Downloads : 0