Original Articles

Comparison of the effectiveness of honey and vitamin C in inhibiting the occurrence of liver fibrosis and lipid peroxidation in biliary obstruction of Wistar Rats

Dudy Kusmartono , Reno Rudiman, Nurhayat Usman

Dudy Kusmartono
Digestive Surgery Division, Department of Surgery, Hasan Sadikin Hospital, Bandung, West Java, Indonesia. Email: dudykusmartono@gmail.com

Reno Rudiman
Digestive Surgery Division, Department of Surgery, Hasan Sadikin Hospital, Bandung, West Java, Indonesia

Nurhayat Usman
Digestive Surgery Division, Department of Surgery, Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Online First: December 08, 2021 | Cite this Article
Kusmartono, D., Rudiman, R., Usman, N. 2021. Comparison of the effectiveness of honey and vitamin C in inhibiting the occurrence of liver fibrosis and lipid peroxidation in biliary obstruction of Wistar Rats. Indonesia Journal of Biomedical Science 15(2): 150-154. DOI:10.15562/ijbs.v15i2.355


Introduction: Jaundice comes from the Greek, a clinical condition with skin color and mucosa to become yellowish. The cases number of obstructive jaundice with choledocholithiasis at Hasan Sadikin Hospital Bandung-Indonesia from 2014 to 2016 were 132 cases. On the other hand, honey and vitamin C, which are supplements that are easy to locate in Indonesia, have antioxidant and hepatoprotective abilities to inhibit liver fibrosis and reduce MDA levels effectively, which is one indicator of lipid peroxidation. Therefore, this study tried to compare the role of honey with vitamin C in inhibiting the occurrence of liver fibrosis and lipid peroxidation.

Methods: This study was an experimental study with a parallel design that aimed to determine the formation of liver fibrosis and plasma malondialdehyde (MDA) values as an indicator of lipid peroxidation in biliary obstruction conditions given honey and vitamin C (treatment group) and without honey and vitamin C (control group) in Wistar rats.

Results: Giving honey 3 mg and vitamin C 225 mg in biliary obstruction for 14 days gave an inhibitory effect on liver fibrosis and lower plasma MDA levels compared to the control group. Also, honey had an inhibitory effect on fibrosis and lower plasma MDA levels compared to vitamin C.

Conclusions: Oral administration of 3 mg honey in biliary obstruction of Wistar rats had better results than 225 mg of vitamin C in inhibiting liver fibrosis and lipid peroxidation.

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