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The relationship between follistatin and sarcopenia in elderly

  • I Gusti Putu Suka Aryana ,
  • Ida Bagus Putu Putrawan ,
  • Ni Ketut Rai Purnami ,
  • RA Tuty Kuswardhani ,
  • I Nyoman Astika ,


Abstract

Introduction: Sarcopenia is a multifactorial condition characterized by progressive and comprehensive mass loss accompanied by skeletal muscle strength or function. It can be triggered by physical inactivity, hormonal changes, energy, protein intake, oxidative stress and inflammatory processes. The state of inactivity underlying sarcopenia is related to follistatin levels.

Methods: an analytical cross-sectional study conducted in Posyandu or Elderly Associations in Denpasar City with subjects aged ≥60 years old started from January 2021 to September 2021. The data collected were anthropometric measurements, muscle mass, grip strength, walking speed and serum follistatin levels. Sarcopenia was diagnosed based on the AWGS criteria. Bivariate analysis was performed using the Mann-Whitney analysis to determine the difference in the mean of the independent variables and the Spearman's test to determine the relationship between sarcopenia and follistatin levels. 

Results: 75 subjects were selected, and 15 (20%) subjects were diagnosed with sarcopenia. The results of the Spearman correlation test of upper arm circumference, waist circumference, calf circumference, SMI, walking speed, hand grip strength and follistatin levels only found a significant negative relationship between waist circumference and follistatin levels r= -0,309, p= 0,016. No differences in mean follistatin levels with sarcopenia and non-sarcopenia group p= 0,516. There was no significant relationship between follistatin levels and sarcopenia p= 0,615.  

Conclusion: There is no correlation between follistatin levels and sarcopenia in the elderly. However, follistatin is inversely correlated with waist circumference.

Keywords: sarcopenia follistatin elderly
Section

References

  1. United Nations. World population ageing. United Nations. 2020. Available from: https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/undesa_pd-2020_world_population_ageing_highlights.pdf.
  2. Kementerian Kesehatan RI. Infodatin situasi lanjut usia (lansia) di Indonesia. Pusat Data dan Informasi Kementerian Kesehatan RI. 2016:1-8.
  3. Badan Pusat Statistik. Statistik Penduduk Lanjut Usia 2020. Badan Pusat Statistik. 2020:1-125.
  4. Arnold A, Egger A, Handschin C. PGC-1 α and myokines in the aging muscle -a mini-review. Gerontology. 2011;57(1):37-43.
  5. Kirkwood TBL. A systematic look at an old problem. Nature. 2008;451(7179):644-7.
  6. Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc. 2020;21(3):300-7.
  7. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing. 2019;48:16-31.
  8. Pratesi A, Tarantini F, Bari MD. Skeletal muscle: an endocrine organ. Clin Cases Miner Bone Metab. 2013;10(1):11-4.
  9. Payette H, Roubenoff R, Jacques PF, Dinarello CA, Wilson PWF, Abad LW, et al. Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: The Framingham heart study. J Am Geriatr Soc. 2003;51(9):1237-43.
  10. Dhillon RJS, Hasni S. Pathogenesis and management of sarcopenia. Clinics in Geriatric Medicine. 2017;33:17-26.
  11. Curcio F, Ferro G, Basile C, Liguori I, Parrella P, Pirozzi F, et al. Biomarkers in sarcopenia: a multifactorial approach. Exp Gerontol. 2016;85:1-8.
  12. Sepulveda PV, Lamon S, Hagg A, Thomson RE, Winbanks CE, Qian H, et al. Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy. Sci Rep. 2015;5:1-11.
  13. Hansen J, Brandt C, Nielsen AR, Hojman P, Whitham M, Febbraio MA, et al. exercise induces a marked increase in plasma follistatin: evidence that follistatin is a contraction-induced hepatokine. Endocrinology. 2011;151(1):164-71.
  14. Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. Journal of Cachexia, Sarcopenia and Muscle. 2022;13:86-99.
  15. Papadopoulou SK, Tsintavis P, Potsaki G, Papandreou D. Differences in the prevalence of sarcopenia in community-dwelling, nursing home and hospitalized individuals: a systematic review and meta-analysis. The Journal of Nutrition Health and Aging. 2019;1-8.
  16. Marguti KM. Schuch NJ, Schwanke CH. Inflammatory markers, sarcopenia and its diagnostic criteria among the elderly: a systematic review. Rev Bras Geriatr Gerontol. 2017;20(3):441-53.
  17. Choi K, Jang HY, Ahn JM, Hwang SH, Chung JW, Choi YS, et al. The association of the serum levels of myostatin, follistatin, and interleukin-6 with sarcopenia, and their impacts on survival in patients with hepatocellular carcinoma. Clinical and Molecular Hepatology. 2020;26:492-505.
  18. Du Y, Xu C, Shi H, Jiang X, Tang W, Wu X. Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community dwelling postmenopausal women. BMC Geriatrics. 2021;21(542):1-10.
  19. Fife E, Kostka J, Kroc L, Guligowska A, Piglowska M, Soltysik B, et al. Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men. BMC Geriatrics. 2018;18(200):1-10.
  20. Liaw FY, Kao TW, Fang WH, Han DS, Chi YC, et al. Increased follistatin associated with decreased gait speed among old adults. Eur J Clin Investig. 2016;46(4):321-7.
  21. Hofmann M, Halper B, Oesen S, Franzke B, Stuparits P, Tschan H, et al. Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women. Experimental Gerontology. 2015;64:35-45.
  22. Sordi CM, Reis-Neto E., Keppeke GD, Shinjo SK, Sato EI. Serum myostatin and follistatin levels in patients with dermatomyositis and polymyositis. Journal of Clinical Rheumatology. 2022;28(1):33-7.
  23. Yaden BC, Croy JE, Wang Y, Wilson JM, Datta-Mannan A, Shetler P, et al. Follistatin: a novel therapeutic for the improvement of muscle regenerations. J Pharmacol Exp Ther. 2014;349:355-71.
  24. Miyamoto T, Carrero JJ, Qureshi AR, Anderstam B, Heimburger O, et al. Circulating follistatin in patients with chronic kidney disease: implications for muscle strength, bone mineral density, inflammation and survival. Clin J Am Soc Nephrol. 2011;6(5):1001-8.
  25. Han X, Møller LLV, De Groote E, Bojsen-Møller KN, Davey J, Henríquez- Olguin C, et al. Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle. J Cachexia, Sarcopenia and Muscle. 2019;1-17.
  26. Winbanks CE, Weeks KL, Thomson RE, Sepulveda P V., Beyer C, Qian H, et al. Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin. J Cell Biol. 2012;197(7):997-1008.
  27. Domin R, Dadej D, Pytka M, Zybek-Kocik A, Ruchala M, Guzik P. Effect of various exercise regimens on selected exercise-induced cytokines in healthy people. International Journal of Environmental Research and Public Health. 2021;18:1-36.
  28. Aryana, IGP Suka. Sarkopenia pada lansia: problem diagnosis dan tatalaksana. Denpasar: Panuduh Atma Waras. 2021.1-120.
  29. Hansen JS, Plomgaard P. Circulating follistatin in relation to energy metabolism. Molecular and Cellular Endocrinology. 2016:1-25.
  30. Flanagan JN, Linder K, Mejhert N, Dungner E, Wahlen K, Decaunes P, et al. role of follistatin in promoting adipogenesis in women. J Clin Endocrinol Metab. 2009;94(8):3003-9.
  31. Oh KJ, Lee DS, Kim WK, Han BS, Lee SC, Bae KH. Metabolic adaptation in obesity and type II diabetes: myokines, adipokines and hepatokines. Int J Mol Sci. 2017;18(8):1-31.

How to Cite

Aryana, I. G. P. S., Ida Bagus Putu Putrawan, Ni Ketut Rai Purnami, RA Tuty Kuswardhani, & I Nyoman Astika. (2022). The relationship between follistatin and sarcopenia in elderly. Indonesia Journal of Biomedical Science, 16(2), 86–90. https://doi.org/10.15562/ijbs.v16i2.382
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