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The association of age, gender, tumor site, and smoking habit with histopathologic types of colorectal carcinoma patients in Wahidin Sudirohusodo Hospital, Makassar, Indonesia

  • Yossy Luther ,
  • Warsinggih ,
  • Firdaus Hamid ,
  • Julianus Aboyaman Uwuratuw ,
  • Erwin Syarifuddin ,
  • Prihantono ,

Abstract

Background: Colorectal carcinoma is the world's third most common type of cancer. The incidence in India is around 7/100,000. From GLOBOCAN data, the incidence of colorectal cancer in Indonesia is 17.2 per 100,000 adult population, with a mortality of 8.4% of all cancer cases. Several parameters were related to the risk of colorectal carcinoma. This study aims to evaluate the association of age, gender, tumor site, and smoking habit with histopathologic types of colorectal carcinoma patients in Wahidin Sudirohusodo Hospital, Makassar, Indonesia.

Methods: The retrospective cross-sectional study was conducted among 158 cases of colorectal carcinoma using a descriptive categorical sampling technique at Wahidin Sudirohusodo Hospital, Makassar, Indonesia, from January-March 2022. The variables assessed in this study were age, gender, tumor site, smoking habit, and histopathologic types of colorectal carcinoma. Data were analyzed using SPSS version 22 for Windows.

Results: There were 158 cases of colorectal carcinoma. According to age, most patients were 45-60 years old (41.1%), while 18-44 years and over 60 years had almost the same proportion. In this study, most of the tumors were found in the distal part, namely the rectum (30.4%), rectosigmoid (18.4%) and sigmoid (17.1%). Most of the subjects were smokers (78.5%). Meanwhile, according to the histological type, 85.4% were adenocarcinomas, followed by mucinous adenocarcinomas (13.3%) and signet ring cell types (1.3%). There is no significant relationship between age, gender, tumor location, and smoking habits with the histopathological type of colorectal carcinoma (p>0.05).

Conclusion: There is no significant relationship between age, gender, tumor location, and smoking habits with the histopathological type of colorectal carcinoma.

Section

References

  1. Mathey MD, Pennella CL, Zubizarreta P. Colorectal carcinoma in children and adolescents. Carcinoma colorrectal en niños y adolescentes. Arch Argent Pediatr. 2021;119(5):e487-e498.
  2. Elsaleh H, Joseph D, Grieu F, Zeps N, Spry N, Iacopetta B. Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer. Lancet. 2000;355(9217):1745-1750.
  3. Hajmanoochehri F, Asefzadeh S, Kazemifar AM, Ebtehaj M. Clinicopathological features of colon adenocarcinoma in Qazvin, Iran: a 16 year study. Asian Pac J Cancer Prev. 2014;15(2):951-955.
  4. Xu AG, Yu ZJ, Jiang B, Wang XY, Zhong XH, Liu JH, Lou QY, et al. Colorectal cancer in Guangdong Province of China: a demographic and anatomic survey. World J Gastroenterol. 2010;16(8):960-965.
  5. Hartono A, Lesmana T. A novel scoring system to predict postoperative mortality after colorectal cancer surgery: a retrospective cohort study. Bali Medical Journal. 2022;11(1):96-102.
  6. Pantow RP, Waleleng BJ, Sedli BP. Profil Adenokarsinoma Kolon di RSUP Prof Dr. R. D. Kandou dan Siloam Hospitals Periode Januari 2016 – Juni 2017. e-CliniC. 2017;5(2):326–331.
  7. White A, Ironmonger L, Steele RJC, Ormiston-Smith N, Crawford C, Seims A. A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK. BMC Cancer. 2018;18(1):906.
  8. Chang LC, Wu MS, Tu CH, Lee YC, Shun CT, Chiu HM. Metabolic syndrome and smoking may justify earlier colorectal cancer screening in men. Gastrointest Endosc. 2014;79(6):961-969.
  9. Schütze M, Boeing H, Pischon T, Rehm J, Kehoe T, Gmel G, et al. Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ. 2011;342:d1584.
  10. Abualkhair WH, Zhou M, Ahnen D, Yu Q, Wu XC, Karlitz JJ. Trends in Incidence of Early-Onset Colorectal Cancer in the United States Among Those Approaching Screening Age. JAMA Netw Open. 2020;3(1):e1920407.
  11. Brenner H, Hoffmeister M, Arndt V, Haug U. Gender differences in colorectal cancer: implications for age at initiation of screening. Br J Cancer. 2007;96(5):828-831.
  12. Steele SR, Park GE, Johnson EK, Martin MJ, Stojadinovic A, Maykel JA, et al. The impact of age on colorectal cancer incidence, treatment, and outcomes in an equal-access health care system. Dis Colon Rectum. 2014;57(3):303-310.
  13. Liang PS, Chen TY, Giovannucci E. Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis. Int J Cancer. 2009;124(10):2406-2415.
  14. Davis DM, Marcet JE, Frattini JC, Prather AD, Mateka JJ, Nfonsam VN. Is it time to lower the recommended screening age for colorectal cancer?. J Am Coll Surg. 2011;213(3):352-361.
  15. Gabriel E, Attwood K, Al-Sukhni E, Erwin D, Boland P, Nurkin S. Age-related rates of colorectal cancer and the factors associated with overall survival. J Gastrointest Oncol. 2018;9(1):96-110.
  16. Aunan JR, Cho WC, Søreide K. The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks. Aging Dis. 2017;8(5):628-642.
  17. Gomez D, Dalal Z, Raw E, Roberts C, Lyndon PJ. Anatomical distribution of colorectal cancer over a 10 year period in a district general hospital: is there a true "rightward shift"?. Postgrad Med J. 2004;80(949):667-669.
  18. Carethers JM. One colon lumen but two organs. Gastroenterology 2011;141(2):411-412.
  19. Carethers JM. Risk factors for colon location of cancer. Transl Gastroenterol Hepatol. 2018;3:76.
  20. Takada H, Ohsawa T, Iwamoto S, Yoshida R, Nakano M, Imada S, et al. Changing site distribution of colorectal cancer in Japan. Dis Colon Rectum. 2002;45(9):1249-54.
  21. Hannan LM, Jacobs EJ, Thun MJ. The association between cigarette smoking and risk of colorectal cancer in a large prospective cohort from the United States. Cancer Epidemiol Biomarkers Prev. 2009;18(12):3362-3367.
  22. Liang PS, Allison J, Ladabaum U, Martinez ME, Murphy CC, Schoen RE, et al. Potential Intended and Unintended Consequences of Recommending Initiation of Colorectal Cancer Screening at Age 45 Years. Gastroenterology. 2018;155(4):950-954.
  23. Compton CC, Fielding LP, Burgart LJ, Conley B, Cooper HS, Hamilton SR, et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000;124(7):979-994.
  24. Compton CC. Updated protocol for the examination of specimens from patients with carcinomas of the colon and rectum, excluding carcinoid tumors, lymphomas, sarcomas, and tumors of the vermiform appendix: a basis for checklists. Cancer Committee. Arch Pathol Lab Med 2000;124(7):1016-1025.
  25. Fleming M, Ravula S, Tatishchev SF, Wang HL. Colorectal carcinoma: Pathologic aspects. J Gastrointest Oncol. 2012;3(3):153-173.
  26. Stewart SL, Wike JM, Kato I, Lewis DR, Michaud F. A population-based study of colorectal cancer histology in the United States, 1998-2001. Cancer. 2006;107(5 Suppl):1128-1141.
  27. Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB, Maisonneuve P. Smoking and colorectal cancer: a meta-analysis. JAMA. 2008;300(23):2765-2778.
  28. Yun SO, Cho YB, Lee WY, Kim HC, Yun SH, Park YA, et al. Clinical Significance of Signet-Ring-Cell Colorectal Cancer as a Prognostic Factor. Ann Coloproctol. 2017;33(6):232-238.
  29. Hosseini S, Bananzadeh AM, Salek R, Zare-Bandamiri M, Kermani AT, Mohammadianpanah M. Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer. Ann Coloproctol. 2017;33(2):57-63.
  30. Park JS, Huh JW, Park YA, Cho YB, Yun SH, Kim HC, et al. Prognostic comparison between mucinous and nonmucinous adenocarcinoma in colorectal cancer. Medicine (Baltimore). 2015;94(15):e658.
  31. Tariq K, Ghias K. Colorectal cancer carcinogenesis: a review of mechanisms. Cancer Biol Med. 2016;13(1):120-135.
  32. Mukund K, Syulyukina N, Ramamoorthy S, Subramaniam S. Right and left-sided colon cancers - specificity of molecular mechanisms in tumorigenesis and progression. BMC Cancer. 2020;20(1):317.
  33. Wang X, Amitay E, Harrison TA, Banbury BL, Berndt SI, Brenner H, et al. Association Between Smoking and Molecular Subtypes of Colorectal Cancer. JNCI Cancer Spectr. 2021;5(4):pkab056.
  34. Wei PL, Lin SY, Chang YJ. Cigarette Smoking and Colorectal Cancer: From Epidemiology to Bench. Journal experimental and Clinical Medicine. 2011:3(6):257-261.

How to Cite

Luther, Y., Warsinggih, Hamid, F., Uwuratuw, J. A., Syarifuddin, E., & Prihantono. (2022). The association of age, gender, tumor site, and smoking habit with histopathologic types of colorectal carcinoma patients in Wahidin Sudirohusodo Hospital, Makassar, Indonesia. Indonesia Journal of Biomedical Science, 16(2), 60–64. https://doi.org/10.15562/ijbs.v16i2.402

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