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High expression of CD73 as a negative predictor of clinical neoadjuvant chemotherapy response in triple-negative breast cancer

  • Silvia Khosasi ,
  • Ni Putu Sriwidyani ,
  • I Wayan Juli Sumadi ,
  • Ni Wayan Winarti ,
  • Ni Putu Ekawati ,
  • I Made Muliarta ,


Abstract

Background: Triple Negative Breast Cancer (TNBC) is one of the breast cancer subtypes with an aggressive clinical course and has a limited therapeutic strategy. Until now, conventional chemotherapy is still used as standard therapy, although it still has an inadequate therapeutic response. One of the chemoresistance mechanisms is likely due to the immunosuppressive effect of CD73-derived adenosine. This study aims to evaluate the high CD73 expression as a negative predictor of clinical neoadjuvant chemotherapy response in TNBC.

Methods: This study was a retrospective case-control study. A total of 46 TNBC patients who received neoadjuvant chemotherapy at Prof Dr. I.G.N.G Ngoerah's Hospital were enrolled. Twenty-three patients with positive neoadjuvant chemotherapy responded as the control group and 23 with negative neoadjuvant chemotherapy responded as the case group. Evaluation of CD73 expression was carried out by immunohistochemistry from a biopsy taken before the patient underwent neoadjuvant chemotherapy. CD73 expression was categorized into low and high based on staining intensity and percentage of the stained tumor cells. Data were analyzed using SPSS version 25.0 for Windows.

Results: Analysis showed a significant relationship between CD73 expression and clinical neoadjuvant chemotherapy response (OR=4.41; 95% CI=1.26-15.41; p=0.017). Multivariate analysis showed CD73 expression (AOR=4.88; 95%CI=1.08-21.99; p=0.039) and T stage (AOR=18.82; 95%CI=1.83-193.00; p=0.013) simultaneously affect clinical neoadjuvant chemotherapy response.

Conclusion: It can be concluded that high expression of CD73 and T stage is an independent predictor of negative clinical neoadjuvant chemotherapy response in TNBC patients.

Keywords: TNBC chemotherapy CD73 Immunohistochemistry
Section

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How to Cite

Khosasi, S., Sriwidyani, N. P., Sumadi, I. W. J., Winarti, N. W., Ekawati, N. P. ., & Muliarta, I. M. (2023). High expression of CD73 as a negative predictor of clinical neoadjuvant chemotherapy response in triple-negative breast cancer. Indonesia Journal of Biomedical Science, 17(1), 94–99. https://doi.org/10.15562/ijbs.v17i1.418
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Silvia Khosasi
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IJBS Journal

Ni Putu Sriwidyani
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IJBS Journal

I Wayan Juli Sumadi
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IJBS Journal

Ni Wayan Winarti
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Ni Putu Ekawati
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I Made Muliarta
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