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Characteristic and risk factors of retinopathy of prematurity in Sanglah Hospital Denpasar: 3-years retrospective study

  • I Wayan Eka Sutyawan ,
  • Maria Vinsensia Lie ,
  • Intan Ade Indraputri ,
  • Made Ayu Surasmiati ,
  • Ari Andayani ,
  • Ni Made Ari Suryati ,

Abstract

Introduction: Retinopathy of prematurity (ROP) is one of the important causes of blindness in children. ROP is characterized by abnormal retinal neovascularization of premature infants.

Purpose: This study aimed to estimate the prevalence of ROP in preterm infants at Sanglah Hospital Bali from 2015-2017 and identify the risk factors predisposing them to ROP.

Methods: This was a retrospective study, observational analysis on premature infants diagnosed as ROP at Sanglah Hospital Bali from January 2015 to December 2017, with a gestational age of 30 weeks or less at birth and a birth weight of 1500 grams or less. Infants whose gestational age was >30 weeks or whose birth weight was >1500 grams were also included. The ophthalmological examinations were initiated between the fourth and sixth weeks of chronological age or 34 weeks of corrected age, whichever was earlier, and were repeated weekly or biweekly as per Indonesian guidelines for ROP screening, until full vascularization of the retina reached zone 3.

Results: Out of 31 infants diagnosed as ROP, 3 (9.7%) cases developed ROP in one eye, and 28 (90,3%) cases in both eyes. They were classified as 23 (74.2%) cases stage 1, and 8 (25,8%) cases stage 2. None of the studied infants presented ROP at stage 3, 4, or 5. The risk for ROP was not significantly associated with birth weight (OR 0.375; 95% CI 0.030 – 4.635), gestational age (OR 0.897; 95% CI 0.792 – 1.015), sepsis (OR 1.111; 95% CI 0.089 – 13.835), blood transfusion (OR 1.111; 95% CI 0.089 – 13.835), and HMD (OR 1.118; 95% CI 0.977 – 1.443).

Conclusions: The data of this study showed that low gestational age, low birth weight, sepsis, oxygen therapy, and blood transfusion may be contribute to the development of ROP, but not significant statistically. Clinicians should be aware of the presence of the additional risk factors when monitoring preterm infants,especially when giving supplemental oxygen therapy.

Section

References

  1. Azad R, Chandra P. Retinopathy of prematurity. J Indian Med Assoc. 2005;103:370-372
  2. Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV. Retinopathy of Prematurity. Indian J Pediatr. 2012;79(4):501-509
  3. Gilbert C, Fielder A, Gordillo L, et al. on behalf of the International NO-ROP Group. Characteristics of babies with severe retinopathy of prematurity in countries with low, moderate and high levels of development: implications for screening programmes. Pediatr Electron Pages. 2005;115:518-525
  4. Dominico R, Davis K, Davis O. Documenting the NICU design dilemma: Comparative patient progress in open-ward and single family room units. J Perinatol. 2011;31:281-288
  5. Fortes FIlho JB, Barros CK, da Costa MC, Procianoy RS. Results of a program for the prevention of blindness caused by retinopathy of prematurity in Southern Brazil. J Pediatr. 2007;83(3):209-216
  6. Smith LEH. Pathogenesis of retinopathy of prematurity. Seminars in Neonatology. 2003;8(6):469-473
  7. International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol. 2005;123(7):991-999
  8. Early Treatment for Retinopathy of Prematurity Cooperative Group. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol. 2003;121(12):1684-1694
  9. Chawla D, Agarwal R, Deorari A. Retinopathy of Prematurity. Indian J Pediatr. 2008;75:73-76
  10. Kim T, Sohn J, Yoon YH. Postnatal risk factors of retinopathy of prematurity. Paediatr Perinat Epidemiol. 2004;18:130-134
  11. Gupta VP, Dhaliwal U, Sharma R. Retinopathy of prematurity risk factors. Indian J Pediatr. 2004;71:887-892
  12. Englert A, Saunders A, Purohit D. The effect of anemia on retinopathy of prematurity in extremely low birth weight infants. J Perinatol. 2001;21:21-26
  13. Ophthalmology AAoPSo. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2013;131(1):189-195
  14. Badriah C, Amir I, Elvioza E, Ifran E. Prevalens and risk factors of retinopathy of prematurity. PI. 2012;52(3):138-144
  15. Darlow BA, Hutchinson JL, Henderson-Smart DJ, Donoghue DA, Simpson JM, Evans NJ. Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network. Pediatrics. 2005 Apr;115(4):990-996
  16. Ingemarsson I. Gender aspecs of preterm birth. Br J Obstet Gynaecol. 2003;110(suppl20):34-38
  17. Lermann VL, Fortes Filho JB, Procianoy RS. The prevalence of retinopathy of prematurity in very low birth weight newborn infants. J Pediatr. 2006;82(1):27-32
  18. Fortes Filho JB, Eckert GU, Procianoy L, Barros CK, Procianoy RS. Incidence and risk factors for retinopathy of prematurity in very low and in extremely low birth weight infants in a unit-based approach in Southern Brazil. Eye. 2009;23(1):25-30
  19. Zepeda-Romero LC, Gutierrez-Padilla JA, Dela Fuente-Torres M, Castellanos EA, Padilla ER, Quinn GE. Detection and treatment for retinopathy of prematurity in Mexico: need for effective programs. J AAPOS. 2008;12(3):225-226
  20. Chaudhari S, Patwardhan V, Vaidya U. Retinopathy of prematurity in a tertiary care center, incidence, risk factors and outcomes. Indian Pediatr. 2009;46:219-224
  21. Smith LE. Pathogenesis of retinopathy of prematurity. Acra Paediatr Suppl. 2002;91:26-28
  22. Shah VA, Yeo CL, Ling YL. Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singapore. 2005;34:169-178
  23. Vinekar A, Dogra M, Sangtam T. Retinopathy of prematurity in Asian Indian babies weighting greater than 1250 gram at birth; ten years data from tertiary care center in a developing country. Indian J Ophthalmol. 2007;55:331-336
  24. Deepak C, Ramesh A, Ashok KD. Retinopathy of prematurity. Indian J Pediatr. 2008;75:73-76
  25. Hirano K, Morinobu T, Kirn H. Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants. Arch Dis Child Fetal Neonatal. 2001;84:188-193

How to Cite

Sutyawan, I. W. E., Lie , M. V., Indraputri , I. A. ., Surasmiati , M. A. ., Andayani, A., & Suryati, N. M. A. . (2023). Characteristic and risk factors of retinopathy of prematurity in Sanglah Hospital Denpasar: 3-years retrospective study. Indonesia Journal of Biomedical Science, 17(1), 13–16. https://doi.org/10.15562/ijbs.v17i1.434

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I Wayan Eka Sutyawan
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Maria Vinsensia Lie
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Intan Ade Indraputri
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Made Ayu Surasmiati
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Ari Andayani
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Ni Made Ari Suryati
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