Background: Colorectal cancer (CRC) is cancer of the colon or rectum and one of the leading causes of cancer-related deaths. The marker for CRC is Carcinoembryonic Antigen (CEA). Lymphocytes play a role in cytotoxic cell death, inhibition of tumor cell proliferation, and migration. Lymphocyte Monocyte Ratio (LMR) is an easy-to-use laboratory biomarker to predict clinical outcomes in patients with colon cancer. This study aims to evaluate the relationship between CEA and LMR levels with the severity of CRC.
Methods: The researcher cross-sectional analyzed 53 CRC patients by taking secondary data from medical records of colorectal cancer patients, CEA, and CBC data at Dr. Wahidin Sudirohusodo Hospital Makassar. The data were grouped and then analyzed statistically. Data analysis was performed using SPSS version 25.0 for Windows
Results: The number of patients with male sex was 38 people (71.7%) and 15 women (28.3%). The age group of the patients ranged from 32 to 84 years, with a mean of 58.1 ± 11.3 years. The most severe degree of CRC was moderate, 29 people (73.6%), followed by mild degree, 8 people (15.1%), and severe degree, 6 people (11.3%). There is a significant negative correlation between LMR and CEA (r=-0.357; p=0.009)
Conclusion: There is a significant negative correlation between LMR and CEA. A decrease in LMR can be associated with a poor prognosis in cancer patients, whereas an increase in LMR before treatment can provide a good prognosis