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Various plant extracts that contain polyphenols and have antidiabetic effects: A literature review


Diabetes mellitus (DM) is a multifactorial disease or chronic metabolic disorder characterized by elevated blood sugar levels and abnormalities in the metabolism of proteins, lipids, and carbohydrates due to inadequate insulin. Diabetes mellitus is a common condition that has a significant impact on health. Indonesia is renowned for having a variety of herbal plants high in antioxidants, notably polyphenols, which can be utilized as a promising alternative in type 2 diabetes. Most plant components have been employed as extracts, and they may have antioxidant and anti-inflammatory qualities connected to conditions like diabetes, atherosclerosis, neurodegenerative illness, or cancer. Through this review, it is hoped that we will gain a better understanding of how antioxidants in plants are a promising alternative in reducing blood glucose in a patient with diabetes mellitus.



  1. American Diabetes Association. Diagnosis and classification of diabetes. Diabetes Care. 2014;37:S81-90.
  2. American Diabetes Association. Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes-2020. Diabetes Care. 2020;43.
  3. American Diabetes Association. Microvascular complications and foot care: Standards of medical care in diabetes—2018. Diabetes Care. 2018;41(Diabetes Care):S105-18.
  4. Miftaraj M et al. Mortality and cardiovascular disease in type 1 and type 2 diabetes. N Engl J Med. 2017;376:1407-18.
  5. American Diabetes Association. Cardiovascular disease and risk management: Standards of medical care in diabetes—2018. Diabetes Care. 2018;41:S86-104.
  6. Najafi A, Pourfarzam M, Zadhoush F. Oxidant/antioxidant status in Type-2 diabetes mellitus patients with metabolic syndrome. J Res Med Sci. 2021;26(1).
  7. Rodríguez-Yoldi MJ. Anti-inflammatory and antioxidant properties of plant extracts. Vol. 10, Antioxidants. 2021.
  8. Salehi B, Ata A, Kumar NVA, Sharopov F, Ramírez-Alarcón K, Ruiz-Ortega A, et al. Antidiabetic potential of medicinal plants and their active components. Vol. 9, Biomolecules. 2019.
  9. Zhang P, Li T, Wu X, Nice EC, Huang C, Zhang Y. Oxidative stress and diabetes: antioxidative strategies. Vol. 14, Frontiers of Medicine. 2020.
  10. Serina JJC, Castilho PCMF. Using polyphenols as a relevant therapy to diabetes and its complications, a review. Vol. 62, Critical Reviews in Food Science and Nutrition. 2022.
  11. Di Lorenzo C, Colombo F, Biella S, Stockley C, Restani P. Polyphenols and human health: The role of bioavailability. Vol. 13, Nutrients. 2021.
  12. Anhê FF, Desjardins Y, Pilon G, Dudonné S, Genovese MI, Lajolo FM, et al. Polyphenols and type 2 diabetes: A prospective review. PharmaNutrition. 2013;1(4).
  13. Aryaeian N, Sedehi SK, Arablou T. Polyphenols and their effects on diabetes management : A review. Med J Islam Repub Iran Med. 2017;2017(31):134.
  14. Agung Alit Suka Astini DA, Gunawan HA, Wirono Aman Santoso RM, Andajani S, Basori A. The Effect Of Soursop Leaf Extract On Pancreatic Beta Cell Count And Fasting Blood Glucose In Male Wistar Rats Exposed To A High-Fat Diet And Streptozotocin. Folia Medica Indones. 2017;53(1).
  15. Wahjuni S, Mayun Laksmiwati AAIA, Manuaba IBP. Antidiabetic effects of inIndonesianay leaves (Syzygium polyanthum) extracts through decreasing advanced glycation end products and blood glucose level on alloxan-induced hyperglycemic wistar rats. Asian J Pharm Clin Res. 2018;11(4).
  16. Inayati NC, Chasanah SN, Inayati D, Limijadi EKS. The effect of hydroetanol extract of ambon banana peel (Musa paradisiaca l.) on reduction blood glucose levels in type 2 diabetes mellitus rats. Pakistan J Med Heal Sci. 2020;14(3).
  17. Erdarwati, Syahruddin R. Antidiabetic Effects of Extract Ethanol Momordica Charantia (Bitter Melon) ong Glucose Blood in Diabetic Rats. EJBPS. 2022;9(11)
  18. Hayati L, Hidayat R. The Effects of Sambiloto Leaf Extract (Andrographis peniculata) on Blood Sugar Regulation: an In Vivo Study. Eureka Herba Indones. 2020;1(1).
  19. Wang B lian, Zhang W ji, Zhao J, Wang F jun, Fan L qiang, Wu Y xin, et al. Gene cloning and expression of a novel hypoglycaemic peptide from Momordica charantia. J Sci Food Agric. 2011;91(13).
  20. Richter E, Geetha T, Burnett D, Broderick TL, Babu JR. The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer’s Disease. Vol. 24, International Journal of Molecular Sciences. 2023.

How to Cite

Wong, M. W., & I Gusti Ayu Artini. (2023). Various plant extracts that contain polyphenols and have antidiabetic effects: A literature review. Indonesia Journal of Biomedical Science, 17(2), 198–201.




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Marta Wangsadinata Wong
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I Gusti Ayu Artini
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