The aging process can be delayed by antioxidant supplements such as pumpkin. It is useful for reducing oxidative stress, inflammation, and cellular aging so that older people will be fitter and happier. This literature review will investigate the effect of pumpkins on inflammaging. Google Scholar, Researchgate, and Mendeley were used as the search engine. The keywords were pumpkin & inflammaging. The effect of pumpkin on geriatric beta-endorphin was analyzed from fourteen articles. Body homeostasis, organ systems, and other changes will reduce the functional capacity from the cellular to the individual level in the inflammaging process. To delay the physiological process of aging, pumpkin has the potential to improve the cognitive, endocrine, musculoskeletal, cardiovascular, and immunological organ systems. The inflammaging can be improved by the effect of pumpkin for a better quality of the aging process.