Skip to main content Skip to main navigation menu Skip to site footer

A rare case of cutaneous metastasis of bladder transitional cell carcinoma

  • Azwar Hashfi ,
  • Ahmad Zulfan Hendri ,
  • Adhika Restanto Purnomo ,


Introduction: The cutaneous metastasis of bladder transitional cell carcinoma (TCC) is uncommon. The number of publications describing this entity is sparse. The cutaneous metastasis manifestation may occur at the time of diagnosis or appear months to years after the diagnosis of bladder TCC.

Case description: A 61-year-old male patient presented with a palpable lump in the right lower back that felt for two months before visiting the urology outpatient clinic for routine postoperative follow-up after radical cystectomy one year before. The patient underwent tumor excision, and the pathological analysis supports the diagnosis of metastatic bladder transitional cell carcinoma. The patient then underwent chemotherapy using the gemcitabine-cisplatin protocol. Two years after the cutaneous lesion was diagnosed, the patient is currently surviving.

Conclusion: Cutaneous metastasis of the bladder TCC is a rare disease condition where possible diagnostic difficulties may occur, and a specific treatment protocol is also yet to be defined. In patients with a previous history of bladder cancer with cutaneous lesions, metastatic disease must be considered in the differential diagnosis.



  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49. doi:
  2. Compérat E, Amin MB, Berney DM, Cree I, Menon S, Moch H, et al. What’s new in WHO fifth edition – urinary tract. Histopathology. 2022;81(4):439–46. doi:
  3. Fujita K, Sakamoto Y, Fujime M, Kitagawa R. Two Cases of Inflammatory Skin Metastasis from Transitional Cell Carcinoma of the Urinary Bladder. Urol Int. 1994;53(2):114–6. doi:
  4. Chitale S v., Morrow D r., Patel R, Gaches C g. c., Ball R y. Cutaneous metastases from transitional cell carcinomas of the bladder and renal pelvis. Br J Urol. 1997;79(2):292–3. doi:
  5. Brownstein MH, Helwig EB. Spread of Tumors to the Skin. Arch Dermatol. 1973 Jan 1;107(1):80–6. doi:
  6. Narayana MAS, Patnayak R, Rukmangadha N, Chowhan AK, Kottu R, Phaneendra BV. Cutaneous metastasis of transitional cell carcinoma of the urinary bladder: Cytological aspect. J Cytol Indian Acad Cytol. 2014;31(1):50–2. doi:
  7. Block CA, Dahmoush L, Konety BR. Cutaneous metastases from transitional cell carcinoma of the bladder. Urology. 2006 Apr;67(4):846.e15-17. doi:
  8. Lin CY, Lee CT, Huang JS, Chang LC. Transitional cell carcinoma metastasis to arm skin from the renal pelvis. Chang Gung Med J. 2003 Jul;26(7):525–9. Accessed May 9, 2023
  9. Atmaca AF, Akbulut Z, Demirci A, Belenli O, Alici S, Balbay DM. Multiple subcutaneous nodular metastases from transitional cell carcinoma of the bladder. Pathol Oncol Res POR. 2007;13(1):70–2. doi:
  10. Schmiedecke R, Perry A, Satter EK. Cutaneous metastasis of a transitional cell carcinoma. Dermatol Online J. 2014 Feb 18;20(2):doj_21541. doi:
  11. Mueller TJ, Wu H, Greenberg RE, Hudes G, Topham N, Lessin SR, et al. Cutaneous metastases from genitourinary malignancies. Urology. 2004 Jun;63(6):1021–6. doi:
  12. Hinshaw M, Stratman E, Warner T, Sharata H. Metastatic transitional cell carcinoma of the bladder presenting as genital edema. J Am Acad Dermatol. 2004 Jul;51(1):143–5. doi:
  13. Gowardhan B, Mathers ME, Feggetter JGW. Twenty-three years of disease-free survival following cutaneous metastasis from a primary bladder transitional cell carcinoma. Int J Urol Off J Jpn Urol Assoc. 2004 Nov;11(11):1031–2. doi:
  14. Salemis NS, Gakis C, Zografidis A, Gourgiotis S. Cutaneous metastasis of transitional cell bladder carcinoma: a rare presentation and literature review. J Cancer Res Ther. 2011;7(2):217–9. doi:
  15. Otto T, Krege S, Suhr J, Rübben H. Impact of surgical resection of bladder cancer metastases refractory to systemic therapy on performance score: a phase II trial. Urology. 2001 Jan;57(1):55–9. doi:

How to Cite

Azwar Hashfi, Hendri, A. Z. ., & Purnomo, A. R. . (2024). A rare case of cutaneous metastasis of bladder transitional cell carcinoma. Indonesia Journal of Biomedical Science, 18(1), 52–54.




Search Panel

Azwar Hashfi
Google Scholar
IJBS Journal

Ahmad Zulfan Hendri
Google Scholar
IJBS Journal

Adhika Restanto Purnomo
Google Scholar
IJBS Journal