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Effect of Channa striata extract on knee osteoarthritis: a systematic review


Knee osteoarthritis (OA) is a common form of joint disease globally. Knee OA treatment is challenging due to the lack of a disease-altering medication. Complementary and alternative medicine for OA is becoming more popular. Channa striata (CS) has been examined as a potential treatment for knee OA. This systematic review used the PRISMA guideline. Evaluation from PubMed, Google Scholar, and ScienceDirect obtained seven articles included in this review based on inclusion and exclusion criteria. Three of them were randomized control trials and four studies were experimental studies with animals. Based on the available evidence from in vivo studies, CS extract can prevent fibrillation and surface irregularities, thus reducing the friction of the joint, and in trial study also showed that the participant's quality of life improved due to the decrease in pain and symptoms of knee osteoarthritis. As a result of its complex chemical makeup, CS may have a variety of beneficial effects, including anti-inflammatory, wound-healing, and pain-relieving capabilities. Several limitations remain in the existing research. These include studies with too small of a sample size, too short of a duration, extract toxicity, an absence of evaluation of structural changes and residual effects after investigational products have ended, and the need to further evaluate specific bioactive components.



  1. Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–30. Available from:
  2. Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020;29–30:100587. Available from:
  3. Cheng DS, Visco CJ. Pharmaceutical Therapy for Osteoarthritis. PM&R. 2012;4(5S). Available from:
  4. Nik Shafii NAH, Yaacob LH, Ishak A, Kadir AA. Traditional and Complementary Medicine Use in Knee Osteoarthritis and its Associated Factors Among Patients in Northeast Peninsular Malaysia. Oman Med J. 2018;33(2):148–53. Available from:
  5. Yang S, Dubé CE, Eaton CB, McAlindon TE, Lapane KL. Longitudinal use of complementary and alternative medicine among older adults with radiographic knee osteoarthritis. Clin Ther. 2013/10/18. 2013;35(11):1690–702. Available from:
  6. Rovati LC, Girolami F, D’Amato M, Giacovelli G. Effects of glucosamine sulfate on the use of rescue non-steroidal anti-inflammatory drugs in knee osteoarthritis: Results from the Pharmaco-Epidemiology of GonArthroSis (PEGASus) study. Semin Arthritis Rheum. 2016;45(4):S34–41. Available from:
  7. Kadir AA, Wahab SZA, Zulkifli MM, Noor NM, Bai S Bin, Haron J. The therapeutic effect of oral Channa striatus extract on primary knee osteoarthritis patients. Agro FOOD Industry Hi Tech. 2014;25(3).
  8. Al-Saffar FJ, Ganabadi S, Fakurazi S, Yaakub H, Lip M. Chondroprotective Effect of Zerumbone on Monosodium Iodoacetate Induced Osteoarthritis in Rats. Journal of Applied Sciences. 2010;10(4):248–60. Available from:
  9. Das BR, Roy A, Khan FR. Cartilage oligomeric matrix protein in monitoring and prognostication of osteoarthritis and its utility in drug development. Perspect Clin Res. 2015;6(1):4–9. Available from:
  10. Lee AS, Ellman MB, Yan D, Kroin JS, Cole BJ, van Wijnen AJ, et al. A current review of molecular mechanisms regarding osteoarthritis and pain. Gene. 2013/07/02. 2013;527(2):440–7. Available from:
  11. Michelle NYT, Shanthi G, Loqman MY. Effect of Orally Administered Channa striatus Extract Against Experimentally-Induced Osteoarthritis in Rabbits. Intern J Appl Res Vet Med. 2004;2(3).
  12. Al-Saffar, Ganabadi S, Fakurazi S, Yaakub H. Zerumbone significantly improved immunoreactivity in the synovium compared to Channa striatus extract in monosodium iodoacetate (MIA)-induced knee osteoarthritis in rat. Journal of Medicinal Plants Research. 2011;5(9):1701–10. Available from:
  13. Al-Saffar FJ, Ganabadi S, Fakuraz S. Response of Channa striatus Extract Against Monosodium Iodoacetate Induced Osteoarthritis in Rats. Journal of Animal and Veterinary Advances. 2011;10(4):460–9. Available from:
  14. Azidah AK, Arifah AK, Roslida AH, Mat Jais AM, Omar J, Sadagatullah AN, et al. A randomized, double-blind study comparing multiple doses of Channa striatus supplementation for knee osteoarthritis. Orient Pharm Exp Med. 2017;17(4):345–54. Available from:
  15. Abdul Kadir A, Abdul Kadir A, Abd Hamid R, Mat Jais AM, Omar J, Sadagatullah AN, et al. Evaluation of Chondroprotective Activity of Channa striatus in Rabbit Osteoarthritis Model. Biomed Res Int. 2019;2019:6979585. Available from:
  16. Ishak A, Abdul Kadir A, Hoi Ling B, Omar J, Sadagatullah AN, Mohd Noor N. Comparative Effectiveness of Channa sriatus Extract Versus Glucosamine Sulphate for the Treatment of Primary Knee Osteoarthritis: A Randomised Controlled Trial. Malaysian Journal of Pharmaceutical Sciences. 2022;20(2):65–77. Available from:
  17. Yu SP, Hunter DJ. Managing osteoarthritis. Aust Prescr. 2015/08/03. 2015;38(4):115–9. Available from:
  18. Lee YH, Woo J-H, Choi SJ, Ji JD, Song GG. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int. 2009;30(3):357–63. Available from:
  19. Laverty S, Girard CA, Williams JM, Hunziker EB, Pritzker KPH. The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rabbit. Osteoarthritis Cartilage. 2010;18:S53–65. Available from:
  20. Inoue H, Shimoyama Y, Hirabayashi K, Kajigaya H, Yamamoto S, Oda H, et al. Production of neuropeptide substance P by synovial fibroblasts from patients with rheumatoid arthritis and osteoarthritis. Neurosci Lett. 2001;303(3):149–52. Available from:
  21. Black C, Clar C, Henderson R, MacEachern C, McNamee P, Quayyum Z, et al. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technol Assess (Rockv). 2009;13(52). Available from:
  22. Al-Saffar FJ, Ganabadi S, Fakuraz S. Response of Channa striatus Extract Against Monosodium Iodoacetate Induced Osteoarthritis in Rats. Journal of Animal and Veterinary Advances. 2011;10(4):460–9. Available from:
  23. Mohamed N, Mohtar N, Razak Hamdan M, Najib Md Salleh S, bin Bai S. Effect of Freeze Drying and Spray Drying Processes to Amino Acids and Fatty Acids Contents in Haruan (Channa striatus) Extract [Internet]. Vol. 6, International Journal of Drug Delivery. 2014. Available from:

How to Cite

Prasetya, I. P. D., & Wiratnaya, I. G. E. . (2024). Effect of Channa striata extract on knee osteoarthritis: a systematic review. Indonesia Journal of Biomedical Science, 18(1), 140–146.




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