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The effectiveness of α1-blockers on uroflowmetry results in patients with Benign Prostatic Hyperplasia (BPH)

  • Ida Bagus Putra Pramana ,
  • Nyoman Gede Prayudi ,
  • Pande Made Wisnu Tirtayasa ,
  • I Wayan Yudiana ,
  • Kadek Budi Santosa ,
  • I Gede Wirya Kusuma Duarsa ,

Abstract

Background: The incidence of benign prostatic hyperplasia (BPH) increases in patients aged over 50 years. Currently, α1-blocker drugs are routinely prescribed to patients with BPH. One of the evaluations that is often used to assess the success of a patient's treatment with medication is a uroflowmetry examination. This study aimed to assess the effectiveness of administering α1-blockers on uroflowmetry results, specifically Q-max, voided volume, and post-void residual volume (PVR).

Methods: This prospective observational cohort study involves patients with BPH who received α1-blocker therapy at one hospital. The uroflowmetry data analyzed includes the Q-max value, voided volume, and PVR, measured before and after one, two, and three months of treatment. The data were analyzed using SPSS version 21.0.

Results: From the results, it was found that there was a significant improvement in Q max, voided volume (VV), and post-void residual volume (PVR) before treatment compared to 1 month after treatment and 3 months after treatment, specifically Qmax 8.86±1.87 ml/sec vs. 11.14±1.97 ml/sec vs. 14.02±1.75 ml/sec (p < 0.05), voided volume 142.45±20.42ml vs. 175.51±32.54 ml vs. 204.33±15.88 ml/sec (p < 0.05), PVR 60.95±13.63 ml vs. 50.92±12.32ml vs. 33.76±14.99 ml (p < 0.05).

Conclusion: Administering α1-blocker drugs to patients with benign prostatic hyperplasia significantly improves Q-max, voided volume, and PVR within one month of treatment, with maximum results observed after three months.

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References

  1. Foster HE, Barry MJ, Dahm P, Gandhi MC, Kaplan SA, Kohler TS, et al. Surgical management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA guideline. J Urol. 2018;200(3):612-619.
  2. Lee SWH, Chan EMC, Lai YK. The global burden of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A systematic review and meta-analysis. Sci Rep. 2017;7(1):7984
  3. Azhar A, Eriawan Agung Nugroho, Ezra Endria Gunadi. Relationship between Prostate Volume and International Prostate Symptom Score (IPSS) Degree of Tamed Prostate Enlargement on Transabdominal Ultrasonography (TAUS) and Transrectal Ultrasonography (TRUS) Examination. BJI. 2021;7(1):112-711.
  4. Chughtai B, Forde JC, Thomas DDM, Laor L, Hossack T, Woo HH, et al. Benign prostatic hyperplasia. Nat Rev Dis Primers. 2016;2(1):16031.
  5. Herman H, Hamid AR, Mochtar CA. Is Inflammation an Age-Related Cause of BPH Progression. Juri. 2011;100(50):50.
  6. Matondang FA, Rahardjo HE. Management of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia by general practitioners in Jakarta. J Prostate int. 2014;2(2):97-103.
  7. Huang W, Wang Q, Chen J, Wu P. Development and validation of the International Consultation on Incontinence Modular Questionnaire for Male Lower Urinary Tract Symptoms (ICIQ‐MLUTS) and the ICIQ‐MLUTS Long Form in Chinese population. LUTS: Lower Urinary Tract Symptoms. 2019;11(4):189-194.
  8. Malik MA, Khan JH, Gondal WS, Bajwa IA. Role of uroflowmetry in lower urinary tract symptoms evaluation due to benign prostatic hyperplasia (BPH). Annals of King Edward Medical University. 2010;16(1):1-10.
  9. Veeratterapillay R, Pickard R, Harding C. The role of uroflowmetry in the assessment and management of men with lower urinary tract symptoms–revisiting the evidence. Journal of Clinical Urology. 2014;7(3):154-158.
  10. Hakim AN, Soetojo, Lestari P. Perbandingan Volume Prostat, Derajat Luts, dan Uroflowmetri Pada Pasien Bph Disertai Diabetes Mellitus Tipe 2 Dengan Pasien Bph Tanpa Diabetes Mellitus Tipe 2 Di RSUD Dr Soetomo Tahun 2011-2015: Universitas Airlangga: Surabaya. 2018.
  11. Lukacs B, Cornu J-N, Aout M, Tessier N, Hodée C, Haab F, et al. Management of lower urinary tract symptoms related to benign prostatic hyperplasia in real-life practice in France: a comprehensive population study. Eur urol. 2013;64(3):493-501.
  12. Lerner LB, McVary, KT, Barry MJ, et al. Management of lower urinary tract symptoms attributed to benign prostatic hyperplasia: AUA Guideline part II, surgical evaluation and treatment. J Urol. 2021;206(4):818-826.
  13. Ariwicaksono SC, Prasetyo RB, Prasadja N, Utomo NB. Efficacy of Silodosin vs Tamsulosin in Patients with Benign Prostatic Hyperplasia: A double blind randomized clinical trial. Int Jour of Applied Pharmaceutics.2019;11(Supl 6):101-103
  14. Koc G, Yilmaz Y, Un S, Akbay K, Akdeniz F. The effect of alpha blockers on uroflowmetric parameters in different voiding positions. Can Urol Assoc J. 2013;7(5-6):E329–E332.
  15. van der Worp H, Jellema P, Hordijk I, van Leeuwen YL, Korteschiel L, Steffens MG, et al. Discontinuation of alpha-blocker therapy in men with lower urinary tract symptoms: a systematic review and meta-analysis. BMJ Open. 2019;9(11):e030405.
  16. Jeh SU, Chung KH, Jung JH, Hyun JS. Improvement of Lower Urinary Tract Symptoms and Sexual Function after Treatment with Alpha-Blocker. Korean Journal of Urology. 2009;50(4):369-374
  17. Mochtar CA, Kiemeney L, Van Riemsdijk M, Barnett G, Laguna M, Debruyne F, et al. Prostate-specific antigen as an estimator of prostate volume in the management of patients with symptomatic benign prostatic hyperplasia. Eur Urol 2003;44(6):695-700.
  18. Veeratterapillay R, Pickard R, Harding C. The role of uroflowmetry in the assessment and management of men with lower urinary tract symptoms–revisiting the evidence. Journal of Clinical Urology. 2014;7(3):154-158.
  19. Oelke M, Höfner K, Jonas U, Jean J, Ubbink DT, Wijkstra H. Diagnostic accuracy of noninvasive tests to evaluate bladder outlet obstruction in men: detrusor wall thickness, uroflowmetry, postvoid residual urine, and prostate volume. J Eur urol. 2007;52(3):827-834.

How to Cite

Pramana, I. B. P., Nyoman Gede Prayudi, Tirtayasa, P. M. W. ., Yudiana, I. W. ., Santosa, K. B. ., & Duarsa, I. G. W. K. . (2024). The effectiveness of α1-blockers on uroflowmetry results in patients with Benign Prostatic Hyperplasia (BPH). Indonesia Journal of Biomedical Science, 18(1), 170–173. https://doi.org/10.15562/ijbs.v18i1.563

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Ida Bagus Putra Pramana
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Nyoman Gede Prayudi
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Pande Made Wisnu Tirtayasa
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I Wayan Yudiana
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Kadek Budi Santosa
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I Gede Wirya Kusuma Duarsa
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