Original Articles

EXPRESSIONS OF STEM CELL FACTOR AND TYROSINASE POSITIVELY CORRELATE WITH EXPRESSION OF Ki-67 IN SEBORRHEIC KERATOSES

IG. A .A. Praharsini , I.G Raka Widiana

IG. A .A. Praharsini
Department of Dermato-Venerology Faculty of Medicine Udayana University/ Sanglah General Hospital, Bali-Indonesia. Email: igaapraharsini@gmail.com

I.G Raka Widiana
Department of Internal Medicine Faculty of Medicine Udayana University, Bali-Indonesia
Online First: January 07, 2015 | Cite this Article
Praharsini, I., Widiana, I. 2015. EXPRESSIONS OF STEM CELL FACTOR AND TYROSINASE POSITIVELY CORRELATE WITH EXPRESSION OF Ki-67 IN SEBORRHEIC KERATOSES. Indonesia Journal of Biomedical Science 9(1). DOI:10.15562/ijbs.v9i1.9


Cellular proliferation of KS will increase secretion of  derivate keratinocyte  factors  that is stem cell factor (SCF)  which is a  melanogenic cytokines  that causes proliferation and differentiation of cells and increase the transcription of tyrosinase enzyme (TYR). It is not clear whether SCF and TYR play a role in cellular proliferation of SK. This study aims to determine the relationship between expressions of SCF and TYR  with  expression of Ki-67 as a proliferative marker in seborrheic keratosis.

This study used a cross sectional design with a sample of 67 SK lesions from patients who visited the Clinic of Dermato-Venerology  Sanglah hospital, Denpasar. Statistical analysis in this study used linear regression test to analyze the relationship between the independent variables (expression of SCF and TYR ) and the dependent variable ( Ki - 67 ).

Stem Cell Factor expression was found to be positively correlated with the expression of Ki-67 (r=0,61, p<0,001) with regression coefficient 0.61 (t=6.22, p<0.001) and constant -49. Correspondingly, the result indicated positive correlation between tyrosinase expression and Ki-67 (r=0,61, p<0,001) with regression coefficient 0.755 (t=8.86, p<0.001) and constant -6.02.  

This study showed a strongly and positive correlation between the expressions of SCF, TYR with  expression of K -67 which is a marker of cell proliferation.
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