Background: Acute Myocardial Infarction (AMI) as cardiovascular disease is a significant cause of death worldwide and requires examining cardiac biomarkers such as Troponin T (TnT) for diagnosis. However, increased troponin levels are often found in non-AMI patients. Soluble Suppression of Tumorigenicity 2 (sST2) as a novel biomarker has known will increase after the occurrence of AMI. This study aims to evaluate the relationship of sST2 and TnT levels in AMI patients at Sanglah General Hospital, Bali, Indonesia

Methods: The study was conducted among 61 participants during August-December 2020 by consecutive sampling. The samples were examined for TnT levels using a Roche Cobass h232 and sST2 with the Human sST2 Elabscience© Enzyme-linked Immunosorbent Assay (ELISA) Kit. Normality and correlation tests were performed between the two parameters. Data were analyzed using SPSS version 17 for Windows.

Results: The average age of participants was 59.5±10.0 years old. Most of the participants were male and had hypertension history in STEMI (71.0% and 67.7%) and NSTEMI (70.0% and 79.0%) groups. There is no significant difference in BMI between STEMI (23.5±3.1 kg/m²) and NSTEMI (24.6±3.8 kg/m²) (p=0.319). However, there was a significant moderate positive correlation between TnT and sST2 levels (r=0.394, p=0.002).

Conclusion: There was an increase in troponin T and sST2 levels in AMI patients at Sanglah Hospital. There is a significant positive correlation between sST2 levels and troponin T levels in AMI patients at Sanglah Hospital.  

Background: Intraperitoneal adhesions are formed due to the inflammatory response in releasing proinflammatory cytokines such as IL-6. Triamcinolone Acetonide (TA) acts as an anti-inflammatory by inhibiting the production and release of IL-6 cytokines. This study aims to determine the effectiveness of triamcinolone acetonide in preventing intraperitoneal adhesions and its effect on assessing IL-6 levels in post-exploratory laparotomy in rats.

Methods: An experimental study was conducted among 40 male Wistar rats from January and March 2021 in the Animal Laboratory of Universitas Padjadjaran, Bandung, Indonesia. Blood samples were taken before treatment and on the 14th day after treatment. In rats, laparotomy and cecum abrasion were performed with a needle. Rats in the treatment group were given triamcinolone acetonide at a dose of 0.1 mg, 0.3 mg, or 0.5 mg. On the 14th day, a microscopic examination of the degree of adhesion was performed. Data were analyzed using SPSS version 20 for Windows.

Results: The results of the Kruskal-Wallis test analysis on the formation of intraperitoneal adhesions microscopically showed a significant difference between the control group and the treatment group (p < 0.001) with the lowest mean rank in the TA group of 0.3 mg (11.4), which stated that this dose was more effective in preventing intraperitoneal adhesions. The One-Way ANOVA test on IL-6 examination had a significant difference in postoperative IL-6 reduction between the control and treatment groups (p < 0.001).

Conclusion: Triamcinolone acetonide was effective in preventing intraperitoneal adhesions and reducing IL-6 levels in post-exploratory laparotomy rats.